Results 41 to 50 of about 2,788 (256)

Fabrication and Evaluation of a Cabbage Harvester Prototype

Agriculture, 2020
A cabbage harvester prototype was fabricated and tested to save time, cost, and labor for harvesting. This harvester was designed for harvesting operations to drive the prototype and control the harvester.
Mohamed Ibrahim El Didamony, Ahmed Mohamed El Shal   +1 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Rock breaking performance of disc cutter assisted by circumferential pre-slotting

Meitan xuebao
Disc cutter has a better hard rock breaking performance due to its undercutting mode. To further improve the mechanized excavation efficiency of hard rock roadway in underground coal mine, the rock wedged performance of disc cutter assisted by ...
Hongxiang JIANG, Xiaodi ZHANG, Kuidong GAO, Ouguo WANG, Shen SONG, Hongsheng LI   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Investigation of Disc Cutter Wear in Tunnel-Boring Machines (TBMs): Integration of Photogrammetry, Measurement with a Caliper, Weighing, and Macroscopic Visual Inspection

Applied Sciences
During the construction of tunnels using tunnel-boring machines (TBMs), the wear of disc cutters is an unavoidable process. The timely replacement of worn disc cutters can have a positive effect on construction time and therefore on costs.
Blaž Janc, Goran Vižintin, Andrej Pal
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rapid assembly bolt connection design method for TBM disc cutter box based on AHP

Advances in Mechanical Engineering
With the TBM disc cutter box as the subject of investigation, this study addresses the intricate and labor-intensive nature of the assembly process in TBM disc cutter box welding assembly.
Chunya Sun, Xuan Zhao, Yanqiu Xiao, Guangzhen Cui, Lianhui Jia, Shengquan Wu, Wei Zhang, Baoping Shang   +7 more
doaj   +1 more source

Experimental Study on the Evolution of Argillization of Mudstone and Cutter Wear during the TBM Tunnelling

Shock and Vibration, 2021
Argillization is a process in which clay-bearing rocks disintegrate into the clay under the action of high temperature, pressure, and water. When tunnel boring machines (TBMs) excavate in the mudstone, argillization takes place, causing the clogging of ...
Kanglei Song, Bolong Liu, Haiqing Yang
doaj   +1 more source