Results 51 to 60 of about 27,701 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Automatic polishing process of plastic injection molds on a 5-axis milling center

, 2009
The plastic injection mold manufacturing process includes polishing operations when surface roughness is critical or mirror effect is required to produce transparent parts.
Pessoles, Xavier, Tournier, Christophe
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Rock breaking performance of disc cutter assisted by circumferential pre-slotting

Meitan xuebao
Disc cutter has a better hard rock breaking performance due to its undercutting mode. To further improve the mechanized excavation efficiency of hard rock roadway in underground coal mine, the rock wedged performance of disc cutter assisted by ...
Hongxiang JIANG, Xiaodi ZHANG, Kuidong GAO, Ouguo WANG, Shen SONG, Hongsheng LI   +5 more
doaj   +1 more source

Experimental investigation on the influence of microwave exposure on the cutting performance of TBM disc cutter cutting of hard rocks

Results in Engineering, 2021
Microwave energy has been demonstrated to be able to assist mechanical rock breaking in geotechnical and mining engineering. The aim of this research is to study the influences of the interaction between microwave energy and rocks on the performance of ...
Gaoming Lu, Jianjun Zhou, Limeng Zhang, Wenyuan Gao   +3 more
doaj   +1 more source

Theoretical Research and Simulation Analysis on the Cutter Spacing of Double Disc Cutters Breaking Rock

KSCE Journal of Civil Engineering, 2019
The arrangement of disc cutter on a cutter head is important to improve the performance of TBM (tunnel boring machine) cutter, cutter life and cutter disc bearing life, then reduce vibration of TBM and reduce the noise. The rock breaking with double disc cutters is the basis of study on the distribution of disc cutter on cutter head, and it plays an ...
Peng Zhou, Jingjing Guo, Jian Sun, Defang Zou   +3 more
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Investigation of Disc Cutter Wear in Tunnel-Boring Machines (TBMs): Integration of Photogrammetry, Measurement with a Caliper, Weighing, and Macroscopic Visual Inspection

Applied Sciences
During the construction of tunnels using tunnel-boring machines (TBMs), the wear of disc cutters is an unavoidable process. The timely replacement of worn disc cutters can have a positive effect on construction time and therefore on costs.
Blaž Janc, Goran Vižintin, Andrej Pal
doaj   +1 more source

Experimental Study on the Evolution of Argillization of Mudstone and Cutter Wear during the TBM Tunnelling

Shock and Vibration, 2021
Argillization is a process in which clay-bearing rocks disintegrate into the clay under the action of high temperature, pressure, and water. When tunnel boring machines (TBMs) excavate in the mudstone, argillization takes place, causing the clogging of ...
Kanglei Song, Bolong Liu, Haiqing Yang
doaj   +1 more source

Assembly Deviation Analysis of New Integrated TBM Disc Cutter and Design of the Supporting Cutter-Changing Robot End-Effector

Applied Sciences, 2022
At present, the replacement of disc cutters of the tunnel boring machine (TBM) is a very important and difficult manual operation. It is meaningful to study disc cutters of TBM replacement with a robot. In this paper, the machining and assembly deviation
Hao Chen, Hao Li, Junzhou Huo, Bowen Yang, Fan Yang   +4 more
doaj   +1 more source