Results 31 to 40 of about 9,522 (251)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Discards in fisheries - a summary of three decades of research at IMARES and LEI [PDF]

, 2011
Discards and the possible ecological and economic effects of discarding are a hot topic in discussions about sustainable fisheries. The perception of the effects of discarding differs between parties and it is influenced by the ecosystem functioning and ...
Quirijns, F.J., Rockmann, C., Overzee, H.M.J., van, Uhlmann, S.S.   +3 more
core  

Status of Fishery Discards and By-Products in Greece and Potential Valorization Scenarios towards a National Exploitation Master Plan

Marine Drugs
The valorization of aquaculture/fishery processing by-products, as well as unavoidable/unwanted catches and discards in Greece, is currently an underutilized activity despite the fact that there are several best practices in Northern Europe and overseas.
Efstratios Roussos, George Triantaphyllidis, Vassiliki Ilia, Konstantinos Tsagarakis, Athanasios Machias, Leto-Aikaterini Tziveleka, Vassilios Roussis, Efstathia Ioannou, Yannis Kotzamanis   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The black scabbardfish (Aphanopus carbo Lowe, 1839) fisheries from the Portuguese mainland and Madeira Island

Scientia Marina, 2009
For several decades, the black scabbardfish (Aphanopus carbo, Lowe 1839) has been a valuable resource for fishing communities in Madeira and more recently for those in mainland Portugal.
Pedro Bordalo-Machado, Ana Cláudia Fernandes, Ivone Figueiredo, Olga Moura, Sara Reis, Graça Pestana, Leonel Serrano Gordo   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Discard sampling of the Dutch beam trawl fleet in 2008 [PDF]

, 2010
Resultaten van het discardbemonsteringsprogramma van de Nederlandse boomkorvisserij in de Noordzee in 2008. In 2008 zijn tien reizen op de Nederlandse boomkorschepen met een motorvermogen groter dan 300 PK vissend met een maaswijdte van 80 mm bemonsterd.
Helmond, A.T.M., van, van Helmond, A.T.M., van Overzee, H.M.J., Overzee, H.M.J., van   +3 more
core  

Impacts on biodiversity from codend and fisher selection in bottom trawl fishing

Frontiers in Marine Science, 2022
Fisheries have important impacts on marine biodiversity. In this work, combined information on the abundance, species richness, diversity indices, species composition, trophic level and vulnerability index were examined for the first-time to detect ...
Chryssi Mytilineou, Chryssi Mytilineou, Bent Herrmann, Bent Herrmann, Bent Herrmann, Christopher J. Smith, Danai Mantopoulou-Palouka, Aikaterini Anastasopoulou, Apostolos Siapatis, Antonello Sala, Persefoni Megalofonou, Nadia Papadopoulou, Vassiliki Vassilopoulou, Caterina Stamouli, Stefanos Kavadas, Evgenia Lefkaditou, Artemis Nicolaidou   +16 more
doaj   +1 more source