Results 31 to 40 of about 12,222 (259)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The black scabbardfish (Aphanopus carbo Lowe, 1839) fisheries from the Portuguese mainland and Madeira Island

Scientia Marina, 2009
For several decades, the black scabbardfish (Aphanopus carbo, Lowe 1839) has been a valuable resource for fishing communities in Madeira and more recently for those in mainland Portugal.
Pedro Bordalo-Machado, Ana Cláudia Fernandes, Ivone Figueiredo, Olga Moura, Sara Reis, Graça Pestana, Leonel Serrano Gordo   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Greek reconstructed fisheries catches show recession rather than recovery

Frontiers in Marine Science
Reliable fisheries catch data are essential for robust stock assessments, ecosystem modelling, and the testing of ecological hypotheses, thereby informing policy decisions that support sustainable ecosystem-based fisheries management.
Konstantinos Touloumis, Donna Dimarchopoulou, Donna Dimarchopoulou, Donna Dimarchopoulou, Manos Koutrakis, Athanassios C. Tsikliras, Athanassios C. Tsikliras   +6 more
doaj   +1 more source

Reconstructed Russian Fisheries Catches in the Barents Sea: 1950-2014

Frontiers in Marine Science, 2018
The management of marine living resources that straddle country borders has historically been a challenge, particularly in cases where political tensions are high.
Sarah Popov, Dirk Zeller
doaj   +1 more source

Impacts on biodiversity from codend and fisher selection in bottom trawl fishing

Frontiers in Marine Science, 2022
Fisheries have important impacts on marine biodiversity. In this work, combined information on the abundance, species richness, diversity indices, species composition, trophic level and vulnerability index were examined for the first-time to detect ...
Chryssi Mytilineou, Chryssi Mytilineou, Bent Herrmann, Bent Herrmann, Bent Herrmann, Christopher J. Smith, Danai Mantopoulou-Palouka, Aikaterini Anastasopoulou, Apostolos Siapatis, Antonello Sala, Persefoni Megalofonou, Nadia Papadopoulou, Vassiliki Vassilopoulou, Caterina Stamouli, Stefanos Kavadas, Evgenia Lefkaditou, Artemis Nicolaidou   +16 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Bycatch and discard survival rate in a small-scale bivalve dredge fishery along the Algarve coast (southern Portugal)

Scientia Marina, 2018
Although the bivalve dredge used on the Algarve coast (southern Portugal) is highly selective for the target species, in some periods of the year the bycatch can exceed the catch of the commercial species.
Mariana Anjos, Fábio Pereira, Paulo Vasconcelos, Sandra Joaquim, Domitília Matias, Karim Erzini, Miguel Gaspar   +6 more
doaj   +1 more source