Results 51 to 60 of about 18,140 (303)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Reconstructed Russian Fisheries Catches in the Barents Sea: 1950-2014

Frontiers in Marine Science, 2018
The management of marine living resources that straddle country borders has historically been a challenge, particularly in cases where political tensions are high.
Sarah Popov, Dirk Zeller
doaj   +1 more source

Discards in global tuna fisheries

, 2017
Monitoring live and dead discarded catch contributes to effective fisheries management and ecological and socioeconomic sustainability. We determined contemporary rates and levels of discards in global tuna fisheries.
Suuronen, Petri, E Gilman, Gilman, Eric, Chaloupka, Milani, P Suuronen, M Chaloupka   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Bycatch and discard survival rate in a small-scale bivalve dredge fishery along the Algarve coast (southern Portugal)

Scientia Marina, 2018
Although the bivalve dredge used on the Algarve coast (southern Portugal) is highly selective for the target species, in some periods of the year the bycatch can exceed the catch of the commercial species.
Mariana Anjos, Fábio Pereira, Paulo Vasconcelos, Sandra Joaquim, Domitília Matias, Karim Erzini, Miguel Gaspar   +6 more
doaj   +1 more source

Impacts on biodiversity from codend and fisher selection in bottom trawl fishing

Frontiers in Marine Science, 2022
Fisheries have important impacts on marine biodiversity. In this work, combined information on the abundance, species richness, diversity indices, species composition, trophic level and vulnerability index were examined for the first-time to detect ...
Chryssi Mytilineou, Chryssi Mytilineou, Bent Herrmann, Bent Herrmann, Bent Herrmann, Christopher J. Smith, Danai Mantopoulou-Palouka, Aikaterini Anastasopoulou, Apostolos Siapatis, Antonello Sala, Persefoni Megalofonou, Nadia Papadopoulou, Vassiliki Vassilopoulou, Caterina Stamouli, Stefanos Kavadas, Evgenia Lefkaditou, Artemis Nicolaidou   +16 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Fishery observers address arctic fishery discards

Environmental Research Letters, 2020
Fishery observers are prevalent actors in the global effort to reduce discards in fisheries, but there remains considerable uncertainty about how effective they are.
Hunter T Snyder, James T Erbaugh
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source