Results 41 to 50 of about 95,075 (278)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Reconstructed Russian Fisheries Catches in the Barents Sea: 1950-2014
Frontiers in Marine Science, 2018 The management of marine living resources that straddle country borders has historically been a challenge, particularly in cases where political tensions are high.
Sarah Popov, Dirk Zeller
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Fishery observers address arctic fishery discards
Environmental Research Letters, 2020 Fishery observers are prevalent actors in the global effort to reduce discards in fisheries, but there remains considerable uncertainty about how effective they are.
Hunter T Snyder, James T Erbaugh
doaj +1 more source
Impacts on biodiversity from codend and fisher selection in bottom trawl fishing
Frontiers in Marine Science, 2022 Fisheries have important impacts on marine biodiversity. In this work, combined information on the abundance, species richness, diversity indices, species composition, trophic level and vulnerability index were examined for the first-time to detect ...
Chryssi Mytilineou +16 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
On Macroscopic Complexity and Perceptual Coding [PDF]
, 2011 The theoretical limits of 'lossy' data compression algorithms are considered. The complexity of an object as seen by a macroscopic observer is the size of the perceptual code which discards all information that can be lost without altering the perception
Scoville, John
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source