Results 81 to 90 of about 223,276 (323)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Strategies Used Throughout the World to Manage Fisheries Discards – Lessons for Implementation of the EU Landing Obligation

The European Landing Obligation, 2018
In many countries, policies regarding reduction of unwanted catch and discards are crafted in response to concerns regarding accountability, conservation, and waste as well as scientific needs to fully account for all sources of fishing mortality.
W. A. Karp, Mike Breen, L. Borges, Mike Fitzpatrick, S. Kennelly, J. Kolding, K. N. Nielsen, Jónas R. Vidarsson, Luis Cocas, D. Leadbitter   +9 more
semanticscholar   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Comparison of diamond- and square-mesh codends in the hake (Merluccius merluccius L. 1758) trawl fishery of the Adriatic Sea (central Mediterranean)

Scientia Marina, 2008
A traditional codend (40 mm diamond mesh) and an experimental codend (40 mm square mesh) made of 2.6 mm diameter knotless PA netting were tested on a commercial trawl net on a sandy-muddy bottom (~70 m depth) of the Adriatic sea in order to assess the ...
Alessandro Lucchetti
doaj   +1 more source

Discard sampling of the Dutch Nephrops fishery in 2007-2008 [PDF]

, 2009
Dit rapport bevat de resultaten van een bemonsteringsprogramme van discards (DCR programma) in de Nederlandse visserij op Noorse kreeft in de Noordzee in 2007 en 2008.
Helmond, A.T.M., van, Overzee, H.M.J., van   +1 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Casting light on the European anchovy: from biology to conservation and industry

Frontiers in Ecology and Evolution
This manuscript explores the role of European anchovies (Engraulis encrasicolus) in the central Mediterranean Region, shedding light on their ecological significance, conservation challenges, and sustainable utilization.
Mirko Mutalipassi, Mirko Mutalipassi, Emanuele D’Anza, Mariagiulia Pugliano, Roberto Firmamento, Carola Murano, Carola Murano, Nadia Ruocco, Chiara Pennesi, Gabriele Procaccini, Teresa Romeo, Teresa Romeo, Antonio Terlizzi, Antonio Terlizzi, Antonio Terlizzi, Vincenzo Peretti   +15 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Production of Fish Protein Hydrolysates from Scyliorhinus canicula Discards with Antihypertensive and Antioxidant Activities by Enzymatic Hydrolysis and Mathematical Optimization Using Response Surface Methodology

Marine Drugs, 2017
Fish discards are of major concern in new EU policies. Alternatives for the management of the new biomass that has to be landed is compulsory. The production of bioactive compounds from fish protein hydrolysates (FPH) has been explored in recent years ...
J. Vázquez, M. Blanco, A. Massa, I. R. Amado, R. Pérez-Martín   +4 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source