Results 21 to 30 of about 872,367 (247)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Imputing Rainfall Data for Flood Simulation in Citarum River, West Java
Sriwijaya Journal of Environment, 2023 The central role of the Citarum River as a buffer to meet the needs of agricultural irrigation, industrial activities, and raw water in the six surrounding districts, including 80% of the population of Jakarta, has experienced a decline in conditions ...
Muhammad Yoga Pratama +2 more
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Glacierized headwater streams as aquifer recharge corridors, subarctic Alaska
Geophysical Research Letters, 2017 Arctic river discharge has increased in recent decades although sources and mechanisms remain debated. Abundant literature documents permafrost thaw and mountain glacier shrinkage over the past decades. Here we link glacier runoff to aquifer recharge via
A. K. Liljedahl +4 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Hospital staffing is usually reduced on weekends, potentially impacting inpatient care and postdischarge coordination of care for patients with acute decompensated heart failure (ADHF).
Louisa A. Mounsey +5 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Contribution of N2O emissions to the atmosphere from Indian monsoonal estuaries [PDF]
Tellus: Series B, Chemical and Physical Meteorology, 2013 Estuaries are known to contribute a significant amount of nitrous oxide (N2O) to the atmosphere; however, the contribution from the Indian estuaries is unknown.
Gijjapu Durga Rao, Vedula V. S. S. Sarma
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Bankfull values in gauge station cross sections of the Raba river – polish Carpathians [PDF]
Acta Scientiarum Polonorum. Formatio Circumiectus, 2017 This paper presents comparison of differents methods of bankfull discharge calculation. The methods used were: Gauckler-Manning [Chow 1959], Williams [1978], Wolman and Leopold [Leopold et al. 1964], Hey and Thorne [Thorne et al. 1997]. Calculations were
Tom Combal +3 more
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