Results 51 to 60 of about 8,035,233 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

FIELD TESTING OF THE SMBF FLUME

Journal of Agricultural Engineering, 2007
At first, in this paper the stage-discharge relationship of a new flume, originally proposed by Samani and Magallanez, for measuring flow discharge in open channels is reviewed.
Costanza Di Stefano, Gian Vito Di Piazza, Vito Ferro   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developing Formulae for combined weir and orifice (case study: EL-Fayoum weirs)

Alexandria Engineering Journal, 2013
In this study, Formulae were developed for rehabilitated weirs (i.e., combined weirs and orifices, weirs with 1 or 2 pipes in their bodies). Several sites of the existing rehabilitated weirs in El-Fayoum were visited. During the visits, measurements were
Ahmed M. El-Belasy
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A First Look at River Discharge Estimation From SWOT Satellite Observations

Geophysical Research Letters
The Surface Water and Ocean Topography (SWOT) satellite has the potential to transform global hydrologic science by offering simultaneous and synoptic estimates of river discharge and other hydraulic variables.
Konstantinos M. Andreadis, Steve P. Coss, Michael Durand, Colin J. Gleason, Travis T. Simmons, Nikki Tebaldi, David M. Bjerklie, Craig Brinkerhoff, Robert W. Dudley, Igor Gejadze, Kevin Larnier, Pierre‐Olivier Malaterre, Hind Oubanas, George H. Allen, Paul D. Bates, Cédric H. David, Alessio Domeneghetti, Omid Elmi, Luciana Fenoglio Marc, Renato Prata de Moraes Frasson, Elisa Friedmann, Pierre‐André Garambois, Jaclyn Gehring, Augusto Getirana, Marissa Hughes, Jonghyun Lee, Pascal Matte, J. Toby Minear, Jérôme Monnier, Aggrey Muhebwa, Mohammad J. Tourian, Tamlin M. Pavelsky, Ryan M. Riggs, Ernesto Rodríguez, Md Safat Sikder, Laurence C. Smith, Cassie Stuurman, Jay Taneja, Angelica Tarpanelli, Jida Wang, Brent A. Williams, Bidhyananda Yadav   +41 more
doaj   +1 more source

Catchment Multisite Discharge Measurements for Hydrological Model Calibration

, 2013
This work has the objective to find and test methodologies for distributed hydrological model calibration starting from discharge measurements. As all distributed models, also FEST-WB demands a large amount of information and parameters.
L. Boscarello, G. Ravazzani, M. Mancini
semanticscholar   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Modeling the Effect of the Loss of Cyclable Lithium on the Performance Degradation of a Lithium-Ion Battery

Energies, 2019
This paper reports a modeling methodology to predict the effect of the loss of cyclable lithium of a lithium-ion battery (LIB) cell comprised of a LiNi0.6Co0.2Mn0.2O2 cathode, natural graphite anode, and an organic electrolyte on the discharge behavior ...
Dongcheul Lee, Boram Koo, Chee Burm Shin, So-Yeon Lee, Jinju Song, Il-Chan Jang, Jung-Je Woo   +6 more
doaj   +1 more source

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source