Results 91 to 100 of about 36,932 (299)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Overcoming the trade-off in reverse osmosis membranes through homologous matching

Nature Communications
The development of cellulose triacetate (CTA)-based reverse osmosis membranes offers a sustainable approach to alleviating the global freshwater crisis, yet overcoming the inherent permeability–selectivity trade-off remains a significant challenge ...
Xinyu Shao, Shiyu Lv, Xiang Qin, Fangchao Cheng, Dongying Hu, Yiqiang Wu, Xiaofei Xu, Shuangliang Zhao   +7 more
doaj   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Innovation: Exploring the knowledge base [PDF]

New types of knowledge, and new ways of organising the production of it, may emerge as knowledge producers respond to the challenges posed by a changing society.
Jan Fagerberg, Koson Sapprasert
core  

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Practical research on the cultivation of inter-disciplinary undergraduate nursing talents in the context of “big health”

BMC Medical Education
Objective Exploring the construction and effectiveness of a inter-disciplinary undergraduate nursing talent cultivation model in the context of“great health”.
Meichun Tan, Huan Liu, Yingqing Xiang, Lin Xiong, Liqin Zou, Liang Fang   +5 more
doaj   +1 more source

MXenes: Reshaping Cross-Disciplinary Innovation and Application Frontiers in Biomedical Engineering

Engineered Science
MXenes have demonstrated significant advantages in smart diagnostic systems, neural engineering interfaces and tissue regeneration engineering due to their abundant surface functional groups, large specific surface area, metal-like conductivity and ...
Wu Wang, Chuang Gong, Jide Zhang, Yihuan Kan, Shaochen Zhou, Min Tang, Yabing Gan, Jingfeng Wang   +7 more
doaj   +1 more source

Innovation In Music II [PDF]

, 2017
Innovation in Music 2015 (InMusic’15) was an international conference organised by KES International and an multi-disciplinary International Programme Committee.

core  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Bringing Discipline into Transdisciplinary Communications -The ISO 56000 Family of Innovation Standards- [PDF]

Journal of Systemics, Cybernetics and Informatics
Trans-disciplinary communication generates new knowledge that may lead to inventions that may be processed into innovations by ambidextrous organizations operating in a global innovation ecosystem.
Rick Fernandez, William Swart
doaj