Results 111 to 120 of about 1,586,483 (335)

Prosecutors and Professional Regulation [PDF]

open access: yes, 2012
Prosecutors often express mistrust of professional regulators, their rules and their processes. This may have been more understandable twenty years ago, when prosecutors perceived that the organized bar had been captured by defense lawyers seeking to use
Green, Bruce A.
core   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

open access: yesAdvanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li   +17 more
wiley   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

open access: yesAdvanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen   +11 more
wiley   +1 more source

On the procedure of public servants to bring disciplinary

open access: yesПроблеми Законності, 2013
The article studies the procedure for bringing public servants disciplined. The place of the disciplinary proceedings in the structure of the administrative process.
В. В. Зуй
doaj   +1 more source

DISCIPLINARY RESPONSIBILITY AND DISCIPLINARY PROCESS IN THE U.S. CIVIL SERVICE SYSTEM

open access: yesBulletin of the South Ural State University series "Law"
The article analyzes the legal basis for disciplinary liability of US civil servants, types of disciplinary sanctions, grounds and procedures for their application. The specificity of disciplinary legal relations is their regulation by a significant number of legislative acts, the provisions of which are detailed by disciplinary guidelines (rules) of ...
openaire   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

open access: yesAdvanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu   +13 more
wiley   +1 more source

Procuring evidence through witness testimony in disciplinary proceedings

open access: yesZbornik Radova Pravnog Fakulteta u Splitu, 2011
By analysing viewpoints of legal theory and the decisions of the Administrative, Constitutional and European Human Rights Courts, the author concludes that giving testimony before a body which is holding disciplinary proceedings against a police official,
Damir Juras
doaj  

PROSECUTION FOR THE COMMISSION OF CORRUPTION OR CORRUPTION-RELATED OFFENSES: THEORETICAL ASPECTS AND PRACTICAL APPLICATION

open access: yesПублічне управління та регіональний розвиток
The article outlines the theoretical aspects of prosecution for corruption or corruption-related offenses and analyzes the national court practice of consideration of relevant cases.
Anastasiia Shulha, Volodymyr Kalytaev
doaj   +1 more source

Ecosystem‐Centered Robot Design: Toward Ecoresorbable Sustainability Robots (ESRs)

open access: yesAdvanced Science, EarlyView.
Robots exploring natural ecosystems can support monitoring and conservation, but must adopt ecosystem‐centered design to avoid pollution, waste, and damage. This review proposes guidelines for co‐designing ecoresorbable sustainability robots (ESRs), uniting materials, robotics, and ecological contexts in a single framework.
Tülin Yılmaz Nayır   +4 more
wiley   +1 more source

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