Results 141 to 150 of about 7,451,038 (316)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Discussions on the talent cultivation of cyber security
网络与信息安全学报, 2016 Cyber security has been formally approved to be the first level discipline in June 2015.How to train the cyber security talents that meet the needs of our country has become an urgent problem to be solved in the discipline construction.Synthetical ...
Jian WENG, Chang-she MA, Liang GU
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Prof. Anwen Liu: promoting knowledge in medicine and discipline construction, bring benefits to patients. [PDF]
J Thorac Dis, 2017 Wang M, Ma L.
europepmc +1 more source
Final report : offsite manufacture in Australia\ud \ud \ud \ud \ud \ud \ud Final report off-site manufacture in Australia \ud \ud [PDF]
, 2007 Off-site Manufacture (OSM) has long been recognised, both in Australia and internationally,\ud as offering numerous benefits to all parties in the construction process. More importantly, it is\ud recognised as a key vehicle for driving improvement within
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Research progress in domestic and foreign and review on clinical nursing theory
Huli yanjiu, 2019 Based on the concept of clinical nursing theory, this article discussed the main academic ideas of clinical nursing theory by using historical literature method and comparative research method, and put forward the significance and application prospect of
朱瑞芳 +5 more
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source