Results 141 to 150 of about 67,482 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Design of cutting tools. Syllabus of the academic discipline [PDF]

open access: yes
Дисципліна "Проєктування різальних інструментів" є вибірковою для підготовки бакалаврів за освітньою програмою «Конструювання та дизайн машин». Метою навчальної дисципліни є формування у здобувачів вищої освіти професійних компетентностей, необхідних для
Солодкий, Валерій Іванович
core   +1 more source

Towards a human resources management approach in supply chain management [PDF]

open access: yes, 2006
Supply chain management (SCM) has grown as a discipline since the field attracted attention in the 1980s. However, it is observed that effective implementation of SCM is limited because the current focus is too task-based and information-centric.
Greenwood, David, Chan, Paul
core  

A Quantum Proxy Signature Scheme Without Restrictions on the Identity and Number of Verifiers

open access: yesEntropy
Quantum digital signatures (QDS) establish a framework for information-theoretically secure authentication in quantum networks. As a specialized extension of QDS, quantum proxy signatures facilitate secure delegation of signing privileges in distributed ...
Siyu Xiong
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Based on the Health Index Model to Research the Discipline Ranking and Discipline Construction Policy [PDF]

open access: yes, 2019
Construction of the world first-class university and the first-class discipline, is a major strategic decision made by the CPC central committee and the state council, in this environment, study of the healthy discipline development in colleges and ...
Zhou, Baohuan
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

What do communication skills mean in the construction discipline? [PDF]

open access: yes, 2011
The establishment of academic standards in a number of disciplines has been the focus of an ongoing Australian Communication has emerged as one of the key threshold learning outcomes in the Australian Learning and Teaching Council (ALTC)-funded project ...
Goldsmith, R, Goldsmith, RJ, Newton, S
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Research progress in domestic and foreign and review on clinical nursing theory

open access: yesHuli yanjiu, 2019
Based on the concept of clinical nursing theory, this article discussed the main academic ideas of clinical nursing theory by using historical literature method and comparative research method, and put forward the significance and application prospect of
朱瑞芳   +5 more
doaj  

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