Results 141 to 150 of about 4,637,860 (323)
Frontiers in Cellular and Infection MicrobiologyBackgroundConstipation is a common digestive system disorder, which is closely related to the intestinal flora. Zhishi Daozhi decoction (ZDD) is a traditional Chinese medicine prescription used to treat constipation caused by indigestion.
Leyao Fang +10 more
doaj +1 more source
Presentation of Culture in Discipline Construction [PDF]
Proceedings of the 4th International Conference on Arts, Design and Contemporary Education (ICADCE 2018), 2018 Feng Wei, Yongyi Qin
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Structured process improvements in facilities management organisations: Best practice case studies in the retail sector [PDF]
Facilities management is a key managerial discipline and large corporations are increasingly recognising its importance in respect of achieving organisational goals and objectives. Enterprises are able to improve their performance by the more effective
Amaratunga, Dilanthi +2 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Research progress in domestic and foreign and review on clinical nursing theory
Huli yanjiu, 2019 Based on the concept of clinical nursing theory, this article discussed the main academic ideas of clinical nursing theory by using historical literature method and comparative research method, and put forward the significance and application prospect of
朱瑞芳 +5 more
doaj
Which Kind of Science Is Construction Management? [PDF]
It is argued that the mainstream views on the nature of construction management are insufficient, and as one consequence of this, the relevance of construction management has been questioned.
Koskela, Lauri
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source