Results 131 to 140 of about 66,969 (302)
Presentation of Culture in Discipline Construction [PDF]
Proceedings of the 4th International Conference on Arts, Design and Contemporary Education (ICADCE 2018), 2018 Feng Wei, Yongyi Qin
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Quantum Proxy Signature Scheme Without Restrictions on the Identity and Number of Verifiers
EntropyQuantum digital signatures (QDS) establish a framework for information-theoretically secure authentication in quantum networks. As a specialized extension of QDS, quantum proxy signatures facilitate secure delegation of signing privileges in distributed ...
Siyu Xiong
doaj +1 more source
A discipline for loop construction
, 1983 A discipline for loop construction is presented which is based on the concept of a well-formed postcondition. A well-formed postcondition is seen to have an implicit logical structure which is made explicit by appropriate. variable binding. This variable
R Geoff Dromey (20240178)
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyBackgroundConstipation is a common digestive system disorder, which is closely related to the intestinal flora. Zhishi Daozhi decoction (ZDD) is a traditional Chinese medicine prescription used to treat constipation caused by indigestion.
Leyao Fang +10 more
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, 2010 The trend of diminished funding, demands for greater efficiency and higher public accountability have led to a rapid expansion of interest in the bibliometric assessment of research performance of universities.
Wong, Johnny, Gray, Jason M.
core
Background Analysis of Traffic Law Discipline Construction
, 2012 The construction of traffic law disciplines can not go beyond the actual conditions of the current economic and social development. It has become the No.1 problem to be solved that what development path on earth the analysis and exploration of this kind ...
ZHANG, Zhiwen
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source