Results 161 to 170 of about 45,126 (263)

Assessing the risk of malaria re-transmission in Anhui Province, China: an integration of spatiotemporal scan statistics and ecological niche modeling. [PDF]

BMC Infect Dis
Liu B, Zhang T, Xue J, Huo S, He H, Tan X, Li W, Li S.   +7 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

A SEER derived prognostic nomogram identifies stage IV metastatic lung squamous cell carcinoma patients who may benefit from primary tumor resection. [PDF]

Discov Oncol
Liu W, Xie S, Wu X, Wang C, Yu X, Du L, Zhang B, Yu Z, Kang M.   +8 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Clinical profile and predictors of guillain-barre syndrome associated pneumonia: a retrospective cohort study. [PDF]

BMC Neurol
Chen L, Gu T, Gao W, Yang H, Feng W, Ren N, Shi Z.   +6 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Deciphering the complexity: a case of kidney failure with co-inheritance of COL4A5 and APOE variants. [PDF]

BMC Nephrol
Zhang X, Jin S, Dai X, Yao C, Zhao Z, Lin F, Shi Y.   +6 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

MIS-TLIF revision surgery for postoperative interbody fusion cage migration via contralateral intervertebral foramen approach: A case report. [PDF]

Medicine (Baltimore)
Xia Q, Chen Q, Chen J, Xu H, Wu T, Zhou J, Wang J, Zhao M.   +7 more
europepmc   +1 more source