Results 51 to 60 of about 4,637,860 (323)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Turning Theory into Practice: A Case Study in the Arts [PDF]

open access: yes, 2019
Students who take art and music courses learn not only content, but also develop new ways of thinking, communicating, and evaluating. Ultimately, such classes teach students to hear and to see, to be comfortable with ambiguity, to examine issues from ...
Lieberman, Ilene D, Parker, Mara E.
core  

Principles of Management Application in Building Construction Projects: Perspectives of Project Managers’ [PDF]

open access: yes, 2020
One of the most crucial factors to consider when setting up and managing organizational activities is the application of management principles. Most of the time, organizational failure is attributed to either as a violation of management principles or an
Abdulkadir, Sani   +2 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

What do communication skills mean in the construction discipline? [PDF]

open access: yes, 2011
The establishment of academic standards in a number of disciplines has been the focus of an ongoing Australian Communication has emerged as one of the key threshold learning outcomes in the Australian Learning and Teaching Council (ALTC)-funded project ...
Goldsmith, RJ, Newton, S
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism

open access: yesBMC Complementary Medicine and Therapies
Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality and morbidity rates globally. Shenmai injection (SMI), a form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF.
Lin Li   +6 more
doaj   +1 more source

Creation and Exploration of the “Organized Fill-in-the-Blank Format” Discipline Construction Model for Forensic Medicine in the New Era

open access: yesFayixue Zazhi
Forensic medicine has been designated as a first-level discipline, presenting new opportunities and challenges for the development of forensic medicine. Since the 1980s, the establishment of forensic medicine discipline and the cultivation of high-level ...
WEI Zhi-wen   +20 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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