Results 51 to 60 of about 66,969 (302)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Technology architecture: the discipline for the future definition of a manifesto
, 2011 The author proposes a reflection on the evolution and possible future developments of Architectural Technology as an academic discipline, in light of its historical roots, through a path that sees it divided into different areas of specialized knowledge,
Gabriella Peretti, Peretti, Gabriella
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Fayixue ZazhiThe 2024 National Education Work Conference pointed out that at the current juncture of the critical period for achieving the goals and tasks of the 14th Five-Year Plan, the implementation of the Education Powerhouse Construction Plan Outline should be ...
QIAO Dong-fang +8 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
BMC Complementary Medicine and TherapiesHeart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality and morbidity rates globally. Shenmai injection (SMI), a form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF.
Lin Li +6 more
doaj +1 more source
Construction and High-Quality Development of Forensic Medicine Discipline at Sichuan University
Fayixue ZazhiWest China Forensic Medicine at Sichuan University （hereinafter referred to as West China Forensic Medicine） has a long history and profound cultural heritage.
LIANG Wei-bo
doaj +1 more source
The theoretical research on the discipline construction of pedagogy [PDF]
Proceedings of the 2015 3rd International Conference on Education, Management, Arts, Economics and Social Science, 2016 Education policy research on the problem of contemporary education, history and the social view of macroscopic idea for people to understand the contemporary education problem provides another perspective or way of thinking. This article through the review and summarize the pedagogy direction of the development and theory research, which is a good ...
openaire +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source