Results 71 to 80 of about 66,969 (302)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Discussions on the talent cultivation of cyber security

网络与信息安全学报, 2016
Cyber security has been formally approved to be the first level discipline in June 2015.How to train the cyber security talents that meet the needs of our country has become an urgent problem to be solved in the discipline construction.Synthetical ...
Jian WENG, Chang-she MA, Liang GU
doaj   +3 more sources

Creation and Exploration of the “Organized Fill-in-the-Blank Format” Discipline Construction Model for Forensic Medicine in the New Era

Fayixue Zazhi
Forensic medicine has been designated as a first-level discipline, presenting new opportunities and challenges for the development of forensic medicine. Since the 1980s, the establishment of forensic medicine discipline and the cultivation of high-level ...
WEI Zhi-wen, WANG Hong-xing, SUN Jun-hong, FAN Hao-liang, SU Hong-liang, WANG Le-le, HE Wen-ting, CHEN Zhe, ZHANG Jie, GUO Xiang-jie, LI Ji, ZHANG Geng-qian, LIANG Xin-hua, YAN Jiang-wei, ZHANG Qiang-qiang, GAO Cai-rong, WANG Ying-yuan, WANG Hong-wei, XIE Jun, ZHU Bo-feng, YUN Ke-ming   +20 more
doaj   +1 more source

Deep Learning as the Disciplined Construction of Tame Objects

CoRR
One can see deep-learning models as compositions of functions within the so-called tame geometry. In this expository note, we give an overview of some topics at the interface of tame geometry (also known as o-minimality), optimization theory, and deep learning theory and practice.
Gilles Bareilles, Allen Gehret, Johannes Aspman, Jana Lepsová, Jakub Marecek   +4 more
openaire   +2 more sources

DesignWorld : a tool for team collaboration in high band\ud virtual environments

, 2005
Current software tools for documenting and developing models of buildings focus on supporting a\ud single user who is a specialist in the specific software used within their own discipline.

core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Machine Learning-Based Ultrasound Radiomics Signature: A Retrospective Analysis for Differentiating Benign from Malignant Non-Mass Lesions in Dense Breasts

International Journal of General Medicine
Wei Chen,* Yudi Xiong,* Zirui Ke Breast Cancer Center, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, National Key Clinical Specialty Discipline Construction Program, Hubei Provincial ...
Chen W, Xiong Y, Ke Z
doaj  

Thoughts and Practices on the Development of Forensic Medicine Discipline in the Perspective of Building a Regional High-Level Medical University

Fayixue Zazhi
Under the background of forensic medicine becoming a first-level discipline, the opportunities and challenges of discipline development coexist. Starting from the actual situation and characteristics of local medical colleges and universities, this paper
CHEN Guang, WANG Rong-shuai, SU Li, ZHANG Yue, LIU Xue-xia, FANG Shi-yong, LIU Zhan-zhan, XU Ya-jun, XU Xiang   +8 more
doaj   +1 more source

An experience of introducing last planner into a UK construction project

, 2003
The Last Planner methodology developed by the Lean Construction Institute is a production control tool which has possible benefits for improving planning in the UK construction industry. Its application has been considered in countries outside the UK but
Porter, Geoff, Johansen, Eric
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source