Results 61 to 70 of about 67,482 (304)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Challenges and aspirations in the development of transfusion medicine and discipline construction in China

open access: yesZhongguo shuxue zazhi
This paper systematically expounds the core challenges and development vision facing transfusion medicine and discipline construction in China under the strategic goals of achieving "Chinese modernization" and "Healthy China".
GUI Rong, YANG Chengmin
doaj   +1 more source

Disciplines scolaires et construction identitaire [PDF]

open access: yesTréma, 2010
Les disciplines faisant le lien entre le monde du travail et les apprentissages scolaires, leur gestion dans l’institution scolaire répercute l’image sociale des professions qui leur sont associées et contribue à sa reproduction. Une enquête internationale sur les représentations scolaires des lecteurs d’Harry Potter (6 langues, plus de 9000 réponses ...
Nicole Biagioli, Jean-Jacques Legendre
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Phased Exploration and Reflections on the High-Quality Development of Rare Disease Centers: Based on the Practice of a Regional Women and Children's Medical Center

open access: yes罕见病研究
Guangzhou Women and Children's Medical Center (GWCMC) established a Rare Disease Medical Center in December 2023 and assumed responsibility for the construction of the Guangdong Provincial Rare Disease Quality Control Center.
LI Shu, LIU Li, ZHOU Wenhao
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Which Kind of Science Is Construction Management? [PDF]

open access: yes
It is argued that the mainstream views on the nature of construction management are insufficient, and as one consequence of this, the relevance of construction management has been questioned.
Koskela, Lauri
core  

Platform-Integrated Synergy and Subspecialty Cluster-Driven Lifelong Management of Pediatric Rare Diseases

open access: yes罕见病研究
With the continuous refinement of China's rare disease prevention and treatment policies, the diagnosis and treatment capacity for rare diseases in China has been steadily improved; however, delayed diagnosis, inadequate transition of care, and poor ...
QIU Liru, LUO Xiaoping
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Interorganizational cost management in Australian construction alliance [PDF]

open access: yes, 2013
Project alliancing/alliance is an alternative to traditional contracting methods in procuring infrastructure projects. Over the past decade, alliance has attracted wide research interest.
Zhang, Guomin   +2 more
core  

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