Results 61 to 70 of about 7,451,038 (316)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Creation and Exploration of the “Organized Fill-in-the-Blank Format” Discipline Construction Model for Forensic Medicine in the New Era

Fayixue Zazhi
Forensic medicine has been designated as a first-level discipline, presenting new opportunities and challenges for the development of forensic medicine. Since the 1980s, the establishment of forensic medicine discipline and the cultivation of high-level ...
WEI Zhi-wen, WANG Hong-xing, SUN Jun-hong, FAN Hao-liang, SU Hong-liang, WANG Le-le, HE Wen-ting, CHEN Zhe, ZHANG Jie, GUO Xiang-jie, LI Ji, ZHANG Geng-qian, LIANG Xin-hua, YAN Jiang-wei, ZHANG Qiang-qiang, GAO Cai-rong, WANG Ying-yuan, WANG Hong-wei, XIE Jun, ZHU Bo-feng, YUN Ke-ming   +20 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Shenmai injection revives cardiac function in rats with hypertensive heart failure: involvement of microbial-host co-metabolism

BMC Complementary Medicine and Therapies
Heart failure (HF) is a complex syndrome marked by considerable expenditures and elevated mortality and morbidity rates globally. Shenmai injection (SMI), a form of Traditional Chinese Medicine-based therapy, has demonstrated effectiveness in treating HF.
Lin Li, Senjie Zhong, Jiahao Ye, Siyuan Hu, Xiajun Xiong, Guangyu Chen, Zhixi Hu   +6 more
doaj   +1 more source

Construction process categorisation towards developing an E-business maturity model [PDF]

, 2014
The rapid pace of change in technology coupled with global economic and environmental changes has had considerable impact on all business sectors. Consequently, organisations are forced to drive towards efficiency savings, productivity improvements and ...
Zhou, Lei, Perera, Srinath (R18622), Rodrigo, Anushi, Perera, Srinath, Udeaja, Chika   +4 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Thoughts and Practices on the Development of Forensic Medicine Discipline in the Perspective of Building a Regional High-Level Medical University

Fayixue Zazhi
Under the background of forensic medicine becoming a first-level discipline, the opportunities and challenges of discipline development coexist. Starting from the actual situation and characteristics of local medical colleges and universities, this paper
CHEN Guang, WANG Rong-shuai, SU Li, ZHANG Yue, LIU Xue-xia, FANG Shi-yong, LIU Zhan-zhan, XU Ya-jun, XU Xiang   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Challenges and aspirations in the development of transfusion medicine and discipline construction in China

Zhongguo shuxue zazhi
This paper systematically expounds the core challenges and development vision facing transfusion medicine and discipline construction in China under the strategic goals of achieving "Chinese modernization" and "Healthy China".
GUI Rong, YANG Chengmin
doaj   +1 more source

Deep Learning as the Disciplined Construction of Tame Objects

CoRR
One can see deep-learning models as compositions of functions within the so-called tame geometry. In this expository note, we give an overview of some topics at the interface of tame geometry (also known as o-minimality), optimization theory, and deep learning theory and practice.
Gilles Bareilles, Allen Gehret, Johannes Aspman, Jana Lepsová, Jakub Marecek   +4 more
openaire   +2 more sources