Results 91 to 100 of about 4,637,860 (323)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
罕见病研究Guangzhou Women and Children's Medical Center (GWCMC) established a Rare Disease Medical Center in December 2023 and assumed responsibility for the construction of the Guangdong Provincial Rare Disease Quality Control Center.
LI Shu, LIU Li, ZHOU Wenhao
doaj +1 more source
Retracted: Discipline Construction and Development of Medical Universities in Complex Environment under Digital Technology and Structural Equation Model. [PDF]
J Healthc Eng, 2023 Engineering JOH.
europepmc +1 more source
Studies of Work: Achieving Hybrid Disciplines in IT Design and Management Studies [PDF]
, 2005 We explore the relationship between ethnomethodology (EM), ethnography and the needs of managers and designers in industry, considering both ethnomethodological and industrial criteria of adequacy and explicating their relationship through the concept of
Rooke, JA, Seymour, D
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Frontiers in PsychologyThis study uses the PISA 2022 ICT questionnaire to examine how students’ ICT interaction behaviours in digital environments predict creative thinking across low, medium, and high performance levels (Class 0–2).
Xinhai Cai +3 more
doaj +1 more source
Zhongguo cuzhong zazhi, 2019 首都医科大学附属北京天坛医院从建立神经内科，搭建神经病学学科建设平台的过程中， 以脑血管病为中心，全面发展神经病学各个亚专业，创建了包括多个神经科学相关临床专业、临床和 基础研究、统计学在内的神经病学中心。本文介绍了天坛医院瞄准国际前沿脉动，创新发展各个学科， 注重青年人才培养，在基础和临床研究领域做出了国际一流的突出成绩，改写国际指南，使得神经病 学科全面发展，其卓有成效的发展模式为全国神经病学中心建设和人才培养提供了典范和经验。 Abstract: This paper introduced
朱丽丽，赵性泉，王春雪，杜万良，王拥军
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Defamiliarizing heavy-contact sports: A critical examination of rugby, discipline, and pleasure [PDF]
, 2009 Pleasure can be regarded as a productive force in the constitution of the social sig-nificance of sport and desiring sport subjects. The organization and use of sport plea-sure has been a relatively marginalized topic of examination.
Pringle, Richard
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
INTEREST GROUPS, VETO POINTS AND ELECTRICITY INFRASTRUCTURE DEPLOYMENT [PDF]
In this paper we examine the effects of interest group pressure and the structure of political institutions on infrastructure deployment by state-owned electric utilities in a panel of 78 countries during the period 1970 – 1994.
Bennet A. Zelner, Witold J. Henisz
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