Results 91 to 100 of about 66,969 (302)

Retracted: Discipline Construction and Development of Medical Universities in Complex Environment under Digital Technology and Structural Equation Model. [PDF]

J Healthc Eng, 2023
Engineering JOH.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multidimensional Challenges and Development Strategies in the Construction of Rare Disease Discipline

罕见病研究
The development of the rare disease discipline is a crucial pathway for enhancing the diagnosis and treatment of rare diseases, cultivating specialized professionals, and fostering technological innovation.
GONG Li, MA Xiaowan, CHENG Nansheng, HE Qian, WAN Zhi   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Contemplation on Development of Traditional Chinese Medicine Rehabilitation Science

康复学报, 2017
Although the concept of Traditional Chinese Medicine Rehabilitation Science began in the 1980s, a lot of rehabilitation treatments were recorded on ancient classics of traditional Chinese medicine (TCM). For example, Huangdi Neijing emphasizes regulating
Xiaodong FENG
doaj  

Exploring the impact of ICT interaction on students’ creative thinking across performance levels: an explainable AI perspective

Frontiers in Psychology
This study uses the PISA 2022 ICT questionnaire to examine how students’ ICT interaction behaviours in digital environments predict creative thinking across low, medium, and high performance levels (Class 0–2).
Xinhai Cai, Xinhai Cai, Yi Bi, Yonggang Feng   +3 more
doaj   +1 more source

以脑血管病为特色神经病学学科建设的探索与实践 Exploration and Practice of Neurology Discipline Construction Characterized by Cerebrovascular Disease

Zhongguo cuzhong zazhi, 2019
首都医科大学附属北京天坛医院从建立神经内科，搭建神经病学学科建设平台的过程中， 以脑血管病为中心，全面发展神经病学各个亚专业，创建了包括多个神经科学相关临床专业、临床和 基础研究、统计学在内的神经病学中心。本文介绍了天坛医院瞄准国际前沿脉动，创新发展各个学科， 注重青年人才培养，在基础和临床研究领域做出了国际一流的突出成绩，改写国际指南，使得神经病 学科全面发展，其卓有成效的发展模式为全国神经病学中心建设和人才培养提供了典范和经验。 Abstract: This paper introduced
朱丽丽，赵性泉，王春雪，杜万良，王拥军
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

[First-Class Nursing Discipline Construction Spearheads the Cultivation of First-Class Talents]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Hu YJ, Li LL, Tian YL, Zhang FY, Liu HH, Qiu C, Li K.   +6 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1643-1660, June 2026.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source