Results 51 to 60 of about 7,425 (229)
Depressed serum IgM levels in SLE are restricted to defined subgroups [PDF]
, 2017 Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls.
arxiv +1 more source
GPA-Tree: Statistical Approach for Functional-Annotation-Tree-Guided Prioritization of GWAS Results [PDF]
arXiv, 2021 Motivation: In spite of great success of genome-wide association studies (GWAS), multiple challenges still remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), each with small or moderate effect sizes. Second, our understanding of the functional mechanisms through which genetic variants are associated ...
arxiv
Efalizumab in the Treatment of Discoid Lupus Erythematosus [PDF]
Archives of Dermatology, 2007 Discoid lupus erythematosus is a chronic inflammatory condition in which the pathogenesis and the role of cell-mediated immunity remains unclear. Currently, the most effective treatments for severe disease are thalidomide, methotrexate, and cyclosporin, although the evidence for this is limited.
Naila Usmani, Mark Goodfield
openaire +2 more sources
High Expression of CDK1 and NDC80 Predicts Poor Prognosis of Bladder Cancer [PDF]
arXiv, 2021 Background: Bladder cancer is the 10th most common cancer worldwide, and its prevalence is increasing, especially in developing countries. Objective: In the present study, we employed gene expression profiles from the GSE163209 data set in the GEO database to identify potential molecular and genetic markers in BC patients.
arxiv
Unusual Presentation of Facial Comedones
Clinical Case Reports, Volume 13, Issue 5, May 2025.Comedonal lupus is a rare variant of chronic cutaneous lupus erythematosus. Its misleading clinical appearance may delay diagnosis, which relies on histopathology and direct immunofluorescence. Early treatment is essential to prevent scarring. ABSTRACT Not all facial comedonal lesions represent acne, nor are they always benign.
Lamis Elyamani +2 more
wiley +1 more source
Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Nature Communications, 2022 Discoid lupus erythematosus (DLE) and systemic LE (SLE) can present as cutaneous lesions. Here the authors characterise an scRNA dataset of cutaneous lesions from these patients and compare these to healthy controls showing differential immune cell ...
Meiling Zheng +16 more
doaj +1 more source
multi-GPA-Tree: Statistical Approach for Pleiotropy Informed and Functional Annotation Tree Guided Prioritization of GWAS Results [PDF]
arXiv, 2023 Genome-wide association studies (GWAS) have successfully identified over two hundred thousand genotype-trait associations. Yet some challenges remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), most with small or moderate effect sizes, making them difficult to detect. Second, many complex traits share a
arxiv
Association between hypertensive disorders of pregnancy and placenta accreta spectrum
Pregnancy, Volume 1, Issue 3, May 2025.Abstract Introduction Placenta accreta spectrum and hypertensive disorders of pregnancy are two significant contributors to severe maternal morbidity and fetal prematurity that may have related but opposite uteroplacental vascular origins. However, the relationship between these conditions is uncertain.
Matthew Givens +6 more
wiley +1 more source
Oman Medical Journal, 2020 Objectives: We sought to determine the prevalence of immune-mediated skin disorders (IMDs), their oral manifestations, and the related comorbidity among Omani patients with IMDs attending the outpatient Department of Dermatology and Dental Clinic at Al ...
Abla Al Ismaili +3 more
doaj +1 more source
A new stochastic differential equation modelling incidence and prevalence with an application to systemic lupus erythematosus in England and Wales, 1995 [PDF]
arXiv, 2012 This article reformulates a common illness-death model in terms of a new system of stochastical differential equations (SDEs). The SDEs are used to estimate epidemiological characteristics and burden of systemic lupus erythematosus in England and Wales in 1995.
arxiv