Results 71 to 80 of about 15,117 (209)

Litifilimab efficacy on skin outcomes in cutaneous lupus erythematosus in the Phase 2 LILAC study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Our findings show that greater proportions of litifilimab‐treated participants than placebo experienced 20%, 50%, 70% or 90% improvements in CLASI‐A score from baseline and CLASI‐A scores of 0–1 or 0–3. Similar results were observed using physician global assessments, supporting the Phase 2 LILAC study primary analysis in CLE.
Victoria P. Werth, Joseph F. Merola, Richard Furie, Kenneth Kalunian, Ronald F. van Vollenhoven, Juanita Romero‐Diaz, Qianyun Li, Weihong Yang, Catherine Barbey   +8 more
wiley   +1 more source

Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese [PDF]

, 2013
OBJECTIVE: This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients. METHODS: Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were
Chan, DTM, Chong, CY, Fung, SKS, Ho, MHK, Lai, WM, Lau, WCS, Lau, YL, Lee, KW, Lee, PPW, Lee, TL, Leung, AMH, Li, PH, Mok, CC, Mok, TMY, Tong, KL, Tse, NKC, Wong, RWS, Wong, SN, Wong, WHS, Yang, W, Ying, SKY   +20 more
core   +1 more source

Possible involvement of keratinocyte‐derived microvesicle particles in human photosensitivity disorders

Photochemistry and Photobiology, EarlyView.
In this model, ROS generated by UVB result in PAFR agonists acting upon the PAFR resulting in MVP generation release via the enzyme aSMase. In photosensitivity, there are increased ROS, resulting in augmented PAF agonists and increased MVP release. This process can be blocked by aSMase inhibitors.
Risha Annamraju, Madison S. Owens, Anita Thyagarajan, Danielle A. Corbin, Catherine M. T. Sherwin, Jade Bryant, Garrett W. Fisher, Winston R. Owens, Alycia Ketter, Aadil Umerani, Craig A. Rohan, Michael G. Kemp, Robyn K. Crow, Jeffrey B. Travers   +13 more
wiley   +1 more source

Antimalarials and the eye [PDF]

, 1989
Following the first reports in 1954 of the beneficial effects of chloroquine in cases of lupus erythematosus, this drug and its numerous derivatives have been used extensively in the treatment of systemic and discoid lupus erythematosus and rheumatoid ...
Coleiro, Joseph A.
core  

Early renal damage assessed by the SLICC/ACR damage index is predictor of severe outcome in lupus patients in Pakistan [PDF]

, 2010
We investigated Patients with systemic lupus erythematosus with the objective of assessing whether early damage accrued in systemic lupus erythematosus as measured by the SLICC/ACR Damage Index predicts mortality in lupus Patients that have been followed
Ahmad, A., Ahmed, Bilal, Habib, H. B., Islam, M., Merchant, D., Rabbani, M. A., Shah, S. M. A., Tahir, S.   +7 more
core   +1 more source

Leucotrichia in Discoid Lupus erythematosus [PDF]

Dermatology, 1992
Sir, The clinical features of discoid lupus erythematosus are quite distinct. The lesions consist of well-defined erythematous slightly infiltrated discoid patches that often show adherent thick scales and follicular plugging. In old lesions, there is often atrophic scarring associated with varying degrees of depigmen-tation and hyperpigmentation.
A J, Kanwar, S, Kaur
openaire   +2 more sources

Dermoscopy of Lichen Planus Follicularis Tumidus: A Case Report With Pattern Analysis and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Lichen planus follicularis tumidus (LPFT) is a rare variant of lichen planus presenting as erythematous to violaceous plaques with significant follicular involvement, most commonly in the retroauricular area. We report a case demonstrating a novel dermoscopic pattern reminiscent of a follicular galaxy, composed of variably sized comedo‐like ...
Vahidehsadat Azhari, Mina Saber
wiley   +1 more source

Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus [PDF]

, 2016
BACKGROUND: Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role in the gender bias of autoimmune diseases although the underlying molecular mechanisms have not yet been fully elucidated.
ALESSANDRI, cristiano, BARBATI, CRISTIANA, Ciarlo, Laura, COLASANTI, TANIA, CONTI, FABRIZIO, Maselli, Angela, Ortona, Elena, Patrizio, Mario, Pierdominici, Marina, SPINELLI, FRANCESCA ROMANA, VALESINI, Guido, VOMERO, MARTA   +11 more
core   +1 more source

An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D).
Laiba Hashmi, Fazeela Bibi, Kishan Chand Lohana, Khalil El Abdi, Zonaira Mushahid, Muhammad Asad Asif, Mahnoor Ilyas, Osvani Leyva Matos, Ariba Munam, Muhammad Saad Sammi, Samaha Kanden Mohammed Shafi, Said Hamid Sadat   +11 more
wiley   +1 more source

Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells [PDF]

, 2012
Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of ...
A Collette, A Collette, A Ephrem, A Kessel, Adrien Six, AE Pires, AM Jacobi, Ana C. Queiros, Ana E. Pires, Ana M. Gabriel, AS Groot De, B Gulwani-Akolkar, B Olivito, B Rosner, Berta Martins, Bárbara Leal, C Joao, C Joao, C Joao, C Olive, C Pannetier, C Scheinecker, Carlos Ferreira, Carlos Vasconcelos, Clara Pereira, Constantin Fesel, Cristina João, D Zennaro, DA Horwitz, E Aubin, E Roux, F Nimmerjahn, F Ria, G Gorochov, G Zandman-Goddard, JC Crispin, JE Fitzgerald, JH Lee, JJ Miles, Jocelyne Demengeot, Jorge Martins, K Talvensarri, KGC Smith, L Diluvio, L Zheng, Luiz F. Goulart, M Bonelli, M Han, M Hirokawa, M Miyara, M Miyara, Margarida Lima, Maria A. Pereira, Maria F. Moraes-Fontes, Maria J. Santos, Marina Bastos, MF Liu, MR Holbrook, MS Maddur, Nuno Costa, PA Fraser, R Pacholczyk, S Gras, S Sakaguchi, SF Massengill, SJ Turner, T Kato, TM Lawson, UG Wagner, W Kolowos, W Press, Wahiba Chaara, X Valencia, Y Arnson, Y Levy, Y Matsumoto, Y Matsumoto, ZC Kou   +77 more
core   +1 more source