Efalizumab in the Treatment of Discoid Lupus Erythematosus [PDF]
Discoid lupus erythematosus is a chronic inflammatory condition in which the pathogenesis and the role of cell-mediated immunity remains unclear. Currently, the most effective treatments for severe disease are thalidomide, methotrexate, and cyclosporin, although the evidence for this is limited.
Naila Usmani, Mark Goodfield
openaire +2 more sources
Vulgar psoriasis and squamous cell carcinoma in a patient with discoid lupus erythematosus
A rare case of a combination of vulgar psoriasis and squamous cell carcinoma of the penis in a patient with discoid lupus erythematosus is described. The literature data on the comorbidity of dermatoses are given.
Valeriy V. Dubensky +3 more
doaj +1 more source
Antimalarials and the eye [PDF]
Following the first reports in 1954 of the beneficial effects of chloroquine in cases of lupus erythematosus, this drug and its numerous derivatives have been used extensively in the treatment of systemic and discoid lupus erythematosus and rheumatoid ...
Coleiro, Joseph A.
core
Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese [PDF]
OBJECTIVE: This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients. METHODS: Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were
Chan, DTM +20 more
core +1 more source
Current treatment strategies: Collagen vascular diseases in children
Of the various collagen vascular diseases seen in pediatric age group, discoid lupus erythematosus, systemic lupus erythematosus, neonatal lupus erythematosus, juvenile dermatomyositis and childhood scleroderma are common and of practical importance to ...
Aparna Palit, Arun C Inamadar
doaj +1 more source
Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus [PDF]
BACKGROUND: Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role in the gender bias of autoimmune diseases although the underlying molecular mechanisms have not yet been fully elucidated.
ALESSANDRI, cristiano +11 more
core +1 more source
Review of treatment for discoid lupus erythematosus
Discoid lupus erythematosus (DLE) is a chronic cutaneous disease characterized by inflammatory plaques that, in the absence of prompt diagnosis and treatment, may lead to disfiguring scarring and skin atrophy. However, there is limited evidence for which
A. C. Garza-Mayers +2 more
semanticscholar +1 more source
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
Broadened T-cell Repertoire Diversity in ivIg-treated SLE Patients is Also Related to the Individual Status of Regulatory T-cells [PDF]
Intravenous IgG (ivIg) is a therapeutic alternative for lupus erythematosus, the mechanism of which remains to be fully understood. Here we investigated whether ivIg affects two established sub-phenotypes of SLE, namely relative oligoclonality of ...
A Collette +77 more
core +1 more source
Rapamycin for refractory discoid lupus erythematosus
Generalized discoid lupus erythematosus can pose a therapeutic challenge for dermatologists. Current treatment emphasizes photoprotection, topical and systemic steroids, and steroid‐sparing immunosuppressive agents if necessary.
Mitchell Herold +4 more
semanticscholar +1 more source

