Results 101 to 110 of about 78,516 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Abrasiveness and Bleaching Level of Toothpastes on Composite Resins: A Quantitative Analysis Using a Novel Brushing Simulator

Applied Sciences
This study assessed the bleaching and abrasiveness levels of different kinds of toothpaste with various RDA values on nanohybrid and microhybrid composite samples using a novel Press-on Force-Guided brushing simulator.
Simge Meseli, Elif Alkan, Bora Korkut, Ozlem Kanar, Dilek Tagtekin   +4 more
doaj   +1 more source

THE CYTOLOGY OF RHOEO DISCOLOR

Annals of Botany, 1908
n ...
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Causes of Discoloration in Preserved Latex

, 1934
Discoloration in preserved latex is attributed to contamination with iron and to the presence of hydrogen sulfide or soluble iron-reactant sulfides.
K. C. Sekar, Edgar Rhodes
core   +1 more source

Combined Effects of Storage Temperature, Storage Time, Display Temperature, and Display Time on Ground Beef Color and Economic Losses

Meat and Muscle Biology
Although various studies have evaluated individual factors that influence meat discoloration, limited research has assessed the effects of multiple ground beef cold chain parameters on color.
Dallas Johnson, Melvin Hunt, Ranjith Ramanathan, Richard A. Mancini, Ryan Feuz   +4 more
doaj   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Comparative Transcriptome Analysis of Temperature-Induced Green Discoloration in Garlic

, 2018
Green discoloration is one of the most important problems that cause low quality of product in the processing of garlic, which can be induced by low-temperature stress. But the mechanism of low temperature-induced green discoloration is poorly understood.
Xuguang Qiao, Xiaozhen Tang, Bingchao Shi, Xiudong Sun, Xiaoming Lu, Ningyang Li, Zhichang Qiu   +6 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Elucidating Basis of Rice Discoloration and Developing Prevention Strategies

, 2020
Economically, discolored rice kernels have less market value, which can seriously impact farm net profit. The reasons for rice discoloration during storage have not been studied extensively and many questions remain.
Mohammadi Shad, Zeinab
core