Results 81 to 90 of about 78,516 (314)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tobacco-associated yellow discoloration of upper lip hair: smoker's mustache [PDF]

, 2015
Background: Hair is susceptible to exogenous sources of discoloration. There are several exogenous etiologies for yellow hair discoloration, including tobacco.Purpose: We describe the clinical features of five men with tobacco-associated yellow ...
Beutler, Bryce D, Cohen, Philip R
core   +1 more source

Novel Antimicrobial Organic Thermal Stabilizer and Co-Stabilizer for Rigid PVC

Molecules, 2012
Biologically active <em>N</em>-benzoyl-4-(<em>N</em>-maleimido)-phenylhydrazide (BMPH) was synthesized and its structure was confirmed by elemental analysis and various spectral tools.
Nadia A. Mohamed, Riham R. Mohamed, Mona M. Fahmy   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of hydrogel-based antibiotic intracanal medicaments on crown discoloration

, 2021
Objectives: This study evaluated the effects of low and moderate concentrations of triple antibiotic paste (TAP) and double antibiotic paste (DAP) loaded into a hydrogel system on crown discoloration and explored whether application of an adhesive ...
Yaghmoor, Rayan B., Platt, Jeffrey A., Chu, Tien Min Gabriel, Spolnik, Kenneth J., Yassen, Ghaeth H.   +4 more
core   +1 more source

Effect of Natural Weathering on Performance of Wood Flour-Recycled Polypropylene Composites

Drvna Industrija
In this study, the effect of natural weathering on the physical and mechanical properties of wood plastic composites (WPC) made from virgin and recycled polypropylene (PP) was studied.
Saeed Kazemi Najafi, Sima Hatami Naderloo, Behbood Mohebby   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Aging and Discoloration of Red Lead (Pb₃O₄) Caused by Reactive Oxygen Species Under Alkaline Conditions

Molecules
Red lead (Pb3O4) has been extensively utilized as a red pigment for centuries. However, the discoloration and blackening of red lead in historical paintings have significantly compromised the aesthetic value of mural artworks.
Zhehan Zhang, Qin Huang, Jiaxing Sun, Qilong Hao, Wenyuan Zhang, Zongren Yu, Bomin Su, Haixia Zhang   +7 more
doaj   +1 more source

Pengaruh Minuman Kopi terhadap Perubahan Warna pada Resin Komposit

Journal of Dentistry Indonesia, 2015
Objective: The aim of this research was to investigate the influence of coffee beverage on hybrid composite resin discoloration. Material and method: This study used hybrid composite resin with A3 color, and was done by soaking composite resin plates in ...
Aprilia Aprilia, Linda Rochyani, Erry Rahardianto   +2 more
doaj   +1 more source