Results 181 to 190 of about 251,997 (259)

The effect of removing point-of-purchase price discounts on college students' future tobacco use susceptibility depends on price sensitivity. [PDF]

Transl Behav Med
Martino SC, Setodji CM, Dunbar MS, Torbatian A, Jenson D, Shadel WG.   +5 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Supermarket Loyalty Card Data for Delivering and Evaluating Dietary Interventions: A Narrative Review. [PDF]

Int J Popul Data Sci
Burgess R, Suhag A, Skatova A.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Nicotine Pouch Advertising and Sales in Australia: A Qualitative Study of Younger People's Experiences. [PDF]

Health Promot J Austr
Jongenelis MI, Li R.
europepmc   +1 more source

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

Advanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan, James R. M. Black, Carlos Martínez‐Ruiz, Kristiana Grigoriadis, Jasmin Fisher, Nicholas McGranahan   +5 more
wiley   +1 more source

Digital marketing techniques within online food retail platforms: a scoping review. [PDF]

BMC Med
Gupta A, Huggins CE, Salahshoornezhad S, Bennett R, Backholer K, Peeters A.   +5 more
europepmc   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

From Waste to Worth: A Multi-Study Investigation of Chinese Consumers' Purchase Intentions Toward Near-Expired Bread. [PDF]

Foods
Gao R, Gao H, Liu Z, Cheng G.
europepmc   +1 more source

Revealing the Giant Electromechanical Effects in Yttria‐Stabilized Zirconia Single Crystal

Advanced Science, EarlyView.
Giant electromechanical responses are uncovered in yttria‐stabilized zirconia single crystal (SC‐YSZ), exhibiting pronounced orientation dependence. The giant electrostriction and piezoelectricity are directly correlated with the long‐range transport kinetics of oxygen vacancies.
Zhuwu Yi, Kai Pan, Chaoming Hu, Luocheng Liao, Zhijian He, Ziwei Guo, Yibao Wu, Changxing Zhao, Shuhong Xie   +8 more
wiley   +1 more source