Results 131 to 140 of about 2,410,696 (333)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

A Study of the Epistemological Foundations of Transcendent Theosophy and Extracting its Implications for Aesthetic Education (Cultural and Art Domains)

open access: yesمسائل کاربردی تعلیم و تربیت اسلامی, 2018
The current study is aimed at examining the epistemological foundations of Transcendent Theosophy in order to extract its implications for aesthetic education as an effective educational method in cultural and art domains.
Zohreh Mottaghi   +3 more
doaj  

朝向問題化的設計思考 —意義驅動課程評鑑引導設計 Towards Problematic Design Thinking: Guiding Meaning-Driven Curriculum Evaluation

open access: yesJournal of Research in Education Sciences
面對世界變革及教育系統之需求,本研究重新從認識論與方法論建立課程評鑑之基礎,並擴大視野,跨越邊界,透過朝向問題化的設計思考,規劃能喚起個體在群體中及對系統的覺知,反思課程實踐,建立具價值與意義之課程評鑑引導設計。本研究主要運用團體討論法,經過8次,每次1-2小時的團體討論,進行「意義驅動與展化的課程評鑑工作坊」之引導設計, 並以關鍵字分析和提問類型進行資料分析,再以參與工作坊學員之意見調查與備課文件作為語料分析之佐證。本研究發現包括:一、融入展化學習及U型理論之問題化的設計思考可生成課程新的理解;二 ...
陳美如 Mei-Ju Chen   +4 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

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