Results 71 to 80 of about 11,180 (306)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The intensional profiles of five hungarian imperative sentence types
Linguistica, 2016 The paper investigates Hungarian imperative sentence types from a pragmaticosemantic point of view. In addition to the baseline imperative, it analyzes types with non-standard intonation pattern and/or discourse markers.
Judit Kleiber +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Discourse Markers as a Strategy of Code-Mixed Discourse in a Galician-Spanish-English Community
Journal of English Studies, 2011 The present paper will try to study the point a specific bilingual community (Spanish-Galician-English in London) is at in the bilingual continuum, whether it is in transition to code mixing or rather there is an emergence of a mixed code, which we can ...
Carmen Pena
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Variation in discourse marker use. Position matters!
, 2014 Discourse markers have been described as typically occurring in utterance-initial position, also described as left-peripheral position. But more recently, discourse markers occurring at utterance-final, or right-peripheral position have attracted quite ...
Discourse-Pragmatic Variation & Change 2 +1 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Discourse structure and information structure : interfaces and prosodic realization
, 2004 In this paper we review the current state of research on the issue of discourse structure (DS) / information structure (IS) interface. This field has received a lot of attention from discourse semanticists and pragmatists, and has made substantial ...
Schlangen, David +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Lithuanian Translation of the Discourse Marker And in Social Media Texts [PDF]
, 2022 Purpose: Discourse markers spark the attention of many linguists and researchers, so linguistics applies computer science in order to study and understand discourse marker use. The problem with discourse markers is their possible ambiguity and polysemy,
Valūnaitė-Oleškevičienė, Giedrė +1 more
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