Results 81 to 90 of about 10,284 (260)
Научный диалогThis article addresses the issue of discourse markers as illuminated by the works of Russian scholars. The relevance of the study is justified by the necessity of theoretical understanding of existing scientific approaches to the examination of these ...
A. V. Kuleshova, T. V. Slastnikova
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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Discourse markers in Shajara-i Tarākima
Humanities & Social Sciences CommunicationsShajara-i Tarākima, transcribed in Classical Chagatai Turkic by Abu al-Ghazi Bahadur Khan during the 17th century, is one of the most significant works in Turkology studies.
Hayrullah Kahya
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Importance marking: Giving reference to the highlighted discourse in academic lectures [PDF]
Ibérica, 2017 This study was an attempt to explore how important points are highlighted in Persian academic lectures. More specifically, this paper was aimed to reach a taxonomy of importance markers based on (a) the discourse functions of importance markers, and (b ...
Javad Zare , Keivanloo-Shahrestanaki
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Ibérica, 2003 The aim of this paper is to investigate what we have called marginal uses of discourse markers and their effect on reading comprehension in Spanish as a foreign language.
Ana Cristina Lahuerta Martínez +1 more
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