Results 41 to 50 of about 2,220 (219)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Vitality and Modernity: Defining the “Folk” in Early Twentieth Century China
, 2005 As usual, the 2005 Chinese Rooster New Year celebrations in Beijing highlighted the annual Earth Temple Fair (Ditan Miaohui) as an indispensable attraction.
Li, Jing
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
, 2018 This chapter discusses the role of religion in the construction of public and political responses to the refugee crisis by taking a closer look at the migration discourse in Polish weekly magazines credited with a major role in shaping public opinion. Presenting a critical discourse analysis based on material published since 2015, Joanna Krotofil and ...
Krotofil, Joanna, Motak, Dominika
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Stigmatised, marginalised and overlooked: health, later life and gender in India and the United Kingdom [PDF]
, 2016 Dominant discourses and conceptual frameworks tend towards stereotypical understandings of what ‘the issues’ are for older people. This forces research, policy framing and everyday discourse down predictable pathways.
Vera-Sanso, Penny
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Girls' jobs for the boys? Men, masculinity and non-traditional occupations [PDF]
, 2002 Occupational segregation by sex remains the most pervasive aspect of the labour market. In the past, most research on this topic has concentrated on explanations of women’s segregation into low paid and low status occupations, or investigations of women ...
Bagilhole, G, Cross, S
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Archetypes and Romanticism in Establishing National Identity as Reflected in Tolkien's the Silmarillion [PDF]
, 2014 This research demonstrates the relationship of fantasy fiction, archetypes, romanticism and nationalism in one of fantasy fiction, namely Tolkien's The Silmarillion. Since fantasy fiction, with the stereotype of escapism, is less appreciated this article
Putra, E. E. (Emil)
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