Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Journal of Medicinal Chemistry, 2022 The ligand-activated nuclear receptor peroxisome-proliferator-activated receptor-γ (PPARG or PPARγ) represents a potential target for a new generation of cancer therapeutics, especially in muscle-invasive luminal bladder cancer where PPARγ is a critical lineage driver.
Douglas L. Orsi +19 more
openaire +2 more sources
First record of the genus Discorhabdella (Porifera, Demospongiae, Poecilosclerida, Crambeidae) from Sagami Bay, Japan with description of two new species [PDF]
ZooKeys, 2021 Two new species of Discorhabdella are described from Sagami Bay, Japan. Discorhabdella has been suggested to have an ancient Tethyan origin according to discovery of their unique pseudoastrose acanthostyles from late Eocene to Oligocene deposits. This is
Yuji Ise +4 more
doaj +3 more sources
Which long-baseline neutrino experiments are preferable? [PDF]
, 2007 We discuss the physics of superbeam upgrades, where we focus on T2KK, a NuMI beam line based experiment NOvA*, and a wide band beam (WBB) experiment independent of the NuMI beam line.
D. Marfatia +5 more
core +1 more source
Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine [PDF]
, 2020 The organisms thriving under extreme conditions better than any other organism living on Earth, fascinate by their hostile growing parameters, physiological features, and their production of valuable bioactive metabolites.
Amoozegar, Mohammad Ali +2 more
core +1 more source
Uncultivated Viral Populations Dominate Estuarine Viromes on the Spatiotemporal Scale
mSystems, 2021 Viruses are ubiquitous and abundant in the oceans, and viral metagenomes (viromes) have been investigated extensively via several large-scale ocean sequencing projects. However, there have not been any systematic viromic studies in estuaries.
Mengqi Sun +5 more
doaj +3 more sources
Cropping systems with perennial vegetation and livestock integration promote soil health
Agricultural & Environmental Letters, 2023 Soil health can differ across cropping systems because of variation in edaphic and management factors. We evaluated how biological indicators of soil health (soil organic matter [SOM], permanganate oxidizable carbon [POXC], mineralizable carbon [MinC ...
Abigail J. Augarten +8 more
doaj +1 more source
Comparison of two reef sites on the north coast of Jamaica over a 15-year period [PDF]
, 2016 This paper compares two reef sites near Discovery Bay, Jamaica, Dairy Bull and Dancing Lady, from 2000 to 2015. At Dairy Bull reef, with low macroalgal cover (8% in 2002 falling to 1% in 2015) and significant number of Diadema antillarum urchins (c.
Crabbe, M. James C.
core +1 more source
NutraceuticalsThis randomized, double-blind, placebo-controlled study investigated Ageratum conyzoides (A. conyzoides) for alleviating osteoarthritis symptoms and improving quality of life.
Amanda Rao +5 more
doaj +1 more source
Re-exploration program for petroleum-rich sags and its significance in Bohai Bay Basin, East China
Petroleum Exploration and Development, 2015 A comprehensive analysis is done to investigate the exploration maturity and exploration potential in the petroleum-rich sags in the Bohai Bay Basin, indicating that the re-exploration program is of great significance. The advances in geological theories,
Xianzheng ZHAO +7 more
doaj +1 more source
Rediscovery and first South African records of the parasitic copepod Cancerilla oblonga Bartsch, 1975 (Crustacea, Cancerillidae) [PDF]
African Invertebrates, 2016 The parasitic copepod Cancerilla oblonga, previously know only from the single holotype female collected from Luderitz Bay, Namibia, is rediscovered in Cape Town, South Africa, where it parasitises the brittlestar Amphiura capensis.
Rebecca B. MacKinnon +2 more
doaj +2 more sources