Results 91 to 100 of about 19,470,595 (297)

Exploration of heterogeneity of treatment effects across exercise-based interventions for knee osteoarthritis

open access: yesOsteoarthritis and Cartilage Open
Objective: Variability exists in the degree of improvement patients experience following exercise-based interventions (EBIs) for knee osteoarthritis (KOA), but understanding of this heterogeneity is limited.
Paul A. Dennis   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

A discovery system for narrative query graphs: entity-interaction-aware document retrieval. [PDF]

open access: yesInt J Digit Libr, 2023
Kroll H   +5 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The veterans affairs health care system national teleoncology service: veteran and provider perspectives and experiences

open access: yesCancer Survivorship Research & Care
Purpose The National TeleOncology Service (NTO) is a clinical service that enables VA oncologists, from across the country, to provide services via telehealth to Veterans with cancer.
Leah L. Zullig   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Children, adults, and machines as discovery systems [PDF]

open access: yesMachine Learning, 1994
1. IntroductionThis is a summary of recent research on the discovery process in which a commonframework for both psychological studies and machine learning (ML) approaches toscientific discovery is described. Early interest in the psychology of science can betraced to Bruner, Goodnow, & Austin (1956), Wason (1960), and Simon (1966, 1973),among others ...
openaire   +3 more sources

Strategies for enhancing the representation of women in clinical trials: an evidence map

open access: yesSystematic Reviews
Background Equitable sex- and gender-based representation in clinical trials is an essential step to ensuring evidence-based care for women. While multi-institutional actions have led to significant improvements in the inclusion of women in trials ...
Karen M. Goldstein   +12 more
doaj   +1 more source

GENERATOR Breast DataMart-The Novel Breast Cancer Data Discovery System for Research and Monitoring: Preliminary Results and Future Perspectives. [PDF]

open access: yesJ Pers Med, 2021
Marazzi F   +16 more
europepmc   +1 more source

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