Results 111 to 120 of about 19,470,595 (297)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
BLEND: A Unified Data Discovery System
2025 IEEE 41st International Conference on Data Engineering (ICDE)Most research on data discovery has so far focused on improving individual discovery operators such as join, correlation, or union discovery. However, in practice, a combination of these techniques and their corresponding indexes may be necessary to support arbitrary discovery tasks. We propose BLEND, a comprehensive data discovery system that supports
Mahdi Esmailoghli +3 more
openaire +2 more sources
Business transformation architecture project : strategic plan
, 2005 Title from p. [1] of PDF document (viewed Oct. 31, 2005).; "MAXIMUS, helping government serve the people"--P.
Ohio Administrative Knowledge System.
core
Development and validation of mRNA expression-based classifiers to predict low-risk thyroid tumors
Frontiers in EndocrinologyBackgroundMolecular variants and fusions in thyroid nodules can provide prognostic information at a population level. However, thyroid cancers harboring the same molecular alterations may exhibit diverse clinical behavior.
Allan Golding +12 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Submitting Figures, Charts and Graphs to DISCOVERY [PDF]
, 2013 This document details how to separate figures, charts, graphs, and illustrations from your DISCOVERY manuscript ...
Honors College Journal, DISCOVERY
core
Cracking the Discovery Code [PDF]
An alternative perspective of discovery services. What effect are they having on content usage at the publisher site and is it the effect that you would expect? What are the common pitfalls and how can you address them?
Sedgwick, Martha +3 more
core +3 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source