Results 101 to 110 of about 541,360 (283)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Regularization of ill-posed mixed variational inequalities with non-monotone perturbations

Journal of Inequalities and Applications, 2011
In this paper, we study a regularization method for ill-posed mixed variational inequalities with non-monotone perturbations in Banach spaces. The convergence and convergence rates of regularized solutions are established by using a priori and a ...
Thuy Nguyen
doaj  

High-resolution data assimilation through stochastic subgrid tensor and parameter estimation from 4DEnVar

Tellus: Series A, Dynamic Meteorology and Oceanography, 2017
In this paper, we explore a dynamical formulation allowing to assimilate high-resolution data in a large-scale fluid flow model. This large-scale formulation relies on a random modelling of the small-scale velocity component and allows to take into ...
Yin Yang, Etienne Mémin
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Zasada przyczynowości a współczynnik podmiotowy w wyjaśnianiu zjawisk politycznych

Świat Idei i Polityki, 2007
The article undertakes the analysis of problem while explaining the discrepancy among the causal principle [theoretical concept understood as hermetic relation between cause and result, according to thesis: definite cause leads always (and only) to ...
Filip Pierzchalski
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Dosed Walking: Under Sign of Health Improving and Rehabilitation

Медицинский вестник Юга России, 2011
Here is shown on the base of the foreign literature review that walking could cause not only positive, but also negative effects. The last one are the result of discrepancy of walking parameters to person’s trained level in the case of inobservance of ...
T. N. Malyarenko, G. V. Chudinov, A. A. Kornienko, Yu. E. Malyarenko   +3 more
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mulla Sadra on the External Difference between Accident and Subject of Philosophical Secondary Intelligible [PDF]

حکمت معاصر, 2014
The Mulla Sadra’s view on the existence of philosophical secondary intelligible has been interpreted and expressed diversely. What is easily understood from Sadra’s statements is that the external aspect of philosophical secondary intelligible is ...
Mohammad Hosseinzadeh
doaj