Results 111 to 120 of about 1,273,558 (290)
Tellus: Series A, Dynamic Meteorology and Oceanography, 2017 In this paper, we explore a dynamical formulation allowing to assimilate high-resolution data in a large-scale fluid flow model. This large-scale formulation relies on a random modelling of the small-scale velocity component and allows to take into ...
Yin Yang, Etienne Mémin
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Discrepancy Principle for Choosing Bandwidths in Kernel Density Estimation
, 2012 We investigate the discrepancy principle for choosing smoothing parameters for kernel density estimation. The method is based on the distance between the empirical and estimated distribution functions.
Thoralf Mildenberger
core
The Morozov Discrepancy Principle for the Elliptic Inverse Problem [PDF]
, 2015 Inverse problems of parameter identification and source identification in partial differential equations are highly ill-posed problems and for their satisfactory theoretical and numerical treatment some sort of regularization is necessary. In this thesis,
Caya, Peter
core +1 more source
Dosed Walking: Under Sign of Health Improving and Rehabilitation
Медицинский вестник Юга России, 2011 Here is shown on the base of the foreign literature review that walking could cause not only positive, but also negative effects. The last one are the result of discrepancy of walking parameters to person’s trained level in the case of inobservance of ...
T. N. Malyarenko +3 more
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Zasada przyczynowości a współczynnik podmiotowy w wyjaśnianiu zjawisk politycznych
Świat Idei i Polityki, 2007 The article undertakes the analysis of problem while explaining the discrepancy among the causal principle [theoretical concept understood as hermetic relation between cause and result, according to thesis: definite cause leads always (and only) to ...
Filip Pierzchalski
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Mulla Sadra on the External Difference between Accident and Subject of Philosophical Secondary Intelligible [PDF]
حکمت معاصر, 2014 The Mulla Sadra’s view on the existence of philosophical secondary intelligible has been interpreted and expressed diversely. What is easily understood from Sadra’s statements is that the external aspect of philosophical secondary intelligible is ...
Mohammad Hosseinzadeh
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source