Results 51 to 60 of about 22,289,271 (287)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Generalized observer forms for discrete-time nonlinear systems [PDF]

Proceedings of the Estonian Academy of Sciences
The paper addresses the problem of transforming single-output discrete-time state equations into the generalized observer form, which comprises a linear observable component and a nonlinear injection term, depending on the inputs, output, and a finite ...
Arvo Kaldmäe, Ülle Kotta, Vadim Kaparin, Tanel Mullari, Maris Tõnso, Ewa Pawłuszewicz   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Robust Time-delayed Control of Nonlinear Discrete-time Systems

, 2023
With the mass production of robotic systems and an emerging new generation of collaborative robots, the requirements are increasing for robust and efficient control strategies, that can successfully deal with disturbances.
Fagiolini A., Pedone S., Trumić Maja
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Supremica – An integrated environment for verification, synthesis and simulation of discrete event systems [PDF]

, 2006
An integrated environment, Supremica, for verification, synthesis and simulation of discrete event systems is presented. The basic model in Supremica is finite automata where the transitions have an associated event together with a guard condition and an
\uc5kesson, Knut, Hugo Flordal, Flordal, Hugo, Malik, Robi, Knut Akesson, Akesson, Knut, Robi Malik, Martin Fabian, Fabian, Martin   +8 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A note on control of a class of discrete-time stochastic systems with distributed delays and nonlinear disturbances [PDF]

, 2010
The official published version of this article can be found at the link below.This paper is concerned with the state feedback control problem for a class of discrete-time stochastic systems involving sector nonlinearities and mixed time-delays. The mixed
Liu, Y, Wei, Guoliang., Liu, X, Wang, Z, Liu, Xiaohui., Wang, Zidong., Yurong Liu (9814022), Z Wang (81545), G Wei (7777079), X Liu (7756691), Wei, G, Liu, Yurong.   +11 more
core   +1 more source