Results 41 to 50 of about 164,309 (313)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Advances in the development of the discrete element method for excavation processes [PDF]
, 2012 This work presents new developments of the discrete element method improving e ciency and accuracy of modelling of rock-like materials, especially in excavation processes.Postprint (published ...
Labra, C. +2 more
core +1 more source
Agriculture, 2023 Due to the lack of accurate discrete element simulation model parameters in the design optimization process of key agricultural machinery components in the whole mechanization technology system of cotton generation, the optimization and improvement of ...
Deli Jiang +5 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Applied Sciences, 2023 Aiming at the lack of a precise discrete element model in the simulation analysis of corn straw crushing, this paper established bond models with different structure and particle models with different properties of corn straw based on Hertz-Mindlin with ...
Wenhang Liu +5 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Numerical prediction of dynamic stability loss of a flexible cylindrical shell in a granular medium [PDF]
Biuletyn Wojskowej Akademii Technicznej, 2019 The paper presents an application of the discrete element method for an analysis of dynamical stability loss of the flexible cylindrical shell section interacting with a model granular medium.
Paweł Szklennik, Grzegorz Bąk
doaj +1 more source
Tensile response of the muscle-tendon complex using discrete element model [PDF]
, 2014 Tear of the muscle-tendon complex (MTC) is one of the main causes of sport injuries (De Labareyre et al. 2005). However, the mechanisms leading to such injury are still unclear (Uchiyama et al. 2011). Before modeling the tear
GRAS, L. +6 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source