Results 41 to 50 of about 2,526,799 (245)
Evaluation of macroscopic stresses in discrete element models of sintering processes [PDF]
Computer Methods in Materials Science, 2015 This paper presents investigation of macroscopic stresses in powder metallurgy process modelled with the discrete element method. The discrete element model belongs to the class of micromechanical models.
Jerzy Rojek +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Applied Sciences, 2021 The behaviour of dry-joint masonry arch structures is highly nonlinear and discontinuous since they are composed of individual discrete blocks. These structures are vulnerable to seismic excitations.
Wangpeng Li +4 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Applied Sciences, 2023 Aiming at the lack of a precise discrete element model in the simulation analysis of corn straw crushing, this paper established bond models with different structure and particle models with different properties of corn straw based on Hertz-Mindlin with ...
Wenhang Liu +5 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Advances in the development of the discrete element method for excavation processes [PDF]
, 2012 This work presents new developments of the discrete element method improving e ciency and accuracy of modelling of rock-like materials, especially in excavation processes.Postprint (published ...
Labra, C. +3 more
core +1 more source
Agriculture, 2023 Due to the lack of accurate discrete element simulation model parameters in the design optimization process of key agricultural machinery components in the whole mechanization technology system of cotton generation, the optimization and improvement of ...
Deli Jiang +5 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source