Results 51 to 60 of about 2,526,799 (245)

An optimized algorithm for discrete element system analysis using CUDA

, 2013
In this paper a parallel computing algorithm for discrete element systems is presented. The discrete model is consisted of finite elements and contacts among the elements. The algorithm is realized using C++ and CUDA and was optimized for NVIDIA GPUs. As
马照松, 李世海, 刘天苹, 冯春
core   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Numerical prediction of dynamic stability loss of a flexible cylindrical shell in a granular medium [PDF]

Biuletyn Wojskowej Akademii Technicznej, 2019
The paper presents an application of the discrete element method for an analysis of dynamical stability loss of the flexible cylindrical shell section interacting with a model granular medium.
Paweł Szklennik, Grzegorz Bąk
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Physical Properties and Experimental Study of Cotton Stalks from Typical Arid Regions of Southern Xinjiang Based on DEM

Agriculture
Using the discrete element method to simulate the interaction between cotton stalks and machinery is an effective approach for analyzing the cotton stalk defibration mechanism and optimizing the structural parameters of cotton stalk defibration equipment.
Guansan Zhu, Xiaowei He, Xufeng Wang, Ji Shi, Jianfei Xing, Long Wang   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Establishment of a Discrete Element Model of Wheat Grains with Different Moisture Contents: A Research Study

Agriculture
The high moisture content of wheat grains in extreme weather, such as continuous rain, can easily cause mildew, and we lack accurate discrete element parameters when conducting a simulation analysis of the rapid dehumidification of high-moisture grains ...
He Li, Guangmeng Guo, Lu Xun, Junhao Lu, Huanhuan Chen, Gongpei Cui   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Discrete Element Model of Different Moisture Hygroscopic Fertilizer Particles

Applied Sciences
The discrete element computer simulation method is an effective tool that enables the study of the interaction mechanism between the fertilizer discharge device.
Xiongfei Chen, Zeyu Sun, Yize Shi, Muhua Liu, Jiajia Yu, Junan Liu   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source