Results 51 to 60 of about 164,309 (313)

Simulation and Experiment of the Spiral Digging End-Effector for Hole Digging in Plug Tray Seedling Substrate

Agronomy, 2022
Usually the planters used in agricultural machinery face two problems: The planters have to spread the soil twice using the tray seed planter, and it is difficult for them to dig the holes before planting.
Xinting Ding, Yongzhe Wei, Zeyu Yan, Yutao Zhu, Dandan Cao, Kai Li, Zhi He, Yongjie Cui   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Discrete mechanics and the Finite Element Method [PDF]

Archive of Applied Mechanics (Ingenieur Archiv), 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chen, J.-B., Guo, H.-Y., Wu, K.
openaire   +2 more sources

A PDE-constrained optimization formulation for discrete fracture network flows [PDF]

, 2013
We investigate a new numerical approach for the computation of the 3D flow in a discrete fracture network that does not require a conforming discretization of partial differential equations on complex 3D systems of planar fractures.
Pieraccini, Sandra, Berrone, Stefano, Scialo', Stefano   +2 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Physical Properties and Experimental Study of Cotton Stalks from Typical Arid Regions of Southern Xinjiang Based on DEM

Agriculture
Using the discrete element method to simulate the interaction between cotton stalks and machinery is an effective approach for analyzing the cotton stalk defibration mechanism and optimizing the structural parameters of cotton stalk defibration equipment.
Guansan Zhu, Xiaowei He, Xufeng Wang, Ji Shi, Jianfei Xing, Long Wang   +5 more
doaj   +1 more source

Considerations for Discrete Element Modeling of Rock Cutting [PDF]

, 2013
This study attempts to build a framework within the Discrete Element Method (DEM) to produce a reliable predictive tool in rock cutting applications, such that the cutting forces and fragmentation process are reasonably estimated. The study is limited to
Mendoza Rizo, Jorge Alejandro
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Discrete Element Model of Different Moisture Hygroscopic Fertilizer Particles

Applied Sciences
The discrete element computer simulation method is an effective tool that enables the study of the interaction mechanism between the fertilizer discharge device.
Xiongfei Chen, Zeyu Sun, Yize Shi, Muhua Liu, Jiajia Yu, Junan Liu   +5 more
doaj   +1 more source