Results 41 to 50 of about 117,272 (312)

Study on Sliding Friction Coefficient in Block Element Method Based on Experimental Method

Applied Sciences
The mechanics and motion behavior of granular materials affect the production and life of human beings. In order to study the influence of the sliding friction coefficients corresponding to different contact types in the block discrete element method on ...
Pengcheng Liu, Jun Liu, Yue Wang
doaj   +1 more source

A review of discrete modeling techniques for fracturing processes in discontinuous rock masses

Journal of Rock Mechanics and Geotechnical Engineering, 2014
The goal of this review paper is to provide a summary of selected discrete element and hybrid finite–discrete element modeling techniques that have emerged in the field of rock mechanics as simulation tools for fracturing processes in rocks and rock ...
A. Lisjak, G. Grasselli
doaj   +1 more source

A block–particle–bar coupled algorithm to simulate tunnel excavation and support

工程科学学报, 2023
During tunnel excavation, the stress of the surrounding rock is redistributed, leading to a local stress concentration around the tunnel. In addition, blasting excavation and other factors lead to a strength reduction of rock mass around the tunnel and ...
Xiao-guang LI, Chang-hong LI, Chun FENG
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Review of calibration strategies for discrete element model in quasi-static elastic deformation

Scientific Reports, 2023
This study first reviewed theories of the mechanical response of structures under loading, and the discrete element method provides a route for studying mechanical response including elastic deformation and structure failure.
Xianyang Liu, Qunwei Wang, Yongwei Wang, Qinxi Dong   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A PDE-constrained optimization formulation for discrete fracture network flows [PDF]

, 2013
We investigate a new numerical approach for the computation of the 3D flow in a discrete fracture network that does not require a conforming discretization of partial differential equations on complex 3D systems of planar fractures.
Pieraccini, Sandra, Berrone, Stefano, Scialo', Stefano   +2 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Parallel coupling strategy for multi-physics applications in eXtended Discrete Element Method [PDF]

, 2020
Multi-physics problems containing discrete particles interacting with fluid phases are widely used industry for example in biomass combustion on a moving grate, particle sedimentation, iron production within a blast furnace, and selective laser melting ...
BESSERON, Xavier, PETERS, Bernhard, MAINASSARA CHEKARAOU, Abdoul Wahid, ROUSSET, Alban   +3 more
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