Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Advances in the development of the discrete element method for excavation processes [PDF]
, 2012 This work presents new developments of the discrete element method improving e ciency and accuracy of modelling of rock-like materials, especially in excavation processes.Postprint (published ...
Labra, C. +3 more
core +1 more source
Study on Sliding Friction Coefficient in Block Element Method Based on Experimental Method
Applied SciencesThe mechanics and motion behavior of granular materials affect the production and life of human beings. In order to study the influence of the sliding friction coefficients corresponding to different contact types in the block discrete element method on ...
Pengcheng Liu, Jun Liu, Yue Wang
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Influence of muscle-tendon complex geometrical parameters on modeling passive stretch behavior with the Discrete Element Method [PDF]
, 2016 The muscle-tendon complex (MTC) is a multi-scale, anisotropic, non-homogeneous structure. It is composed of fascicles, gathered together in a conjunctive aponeurosis. Fibers are oriented into the MTC with a pennation angle. Many MTC models use the Finite
LAPORTE, Sébastien +6 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Discrete element method, a tool to investigate complex thermo mechanical behaviour: application to friction stir welding [PDF]
, 2009 In material forming or cutting, the contact zone between the tool and the working piece is often very difficult to analyse because of diverse local phenomena. In the special case of FSW, a specific difficulty is the study of material mixing. In this work,
I. Terreros +11 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Numerical implementation of the eXtended Finite Element Method for dynamic crack analysis [PDF]
, 2008 A numerical implementation of the eXtended Finite Element Method (X-FEM) to analyze crack propagation in a structure under dynamic loading is presented in this paper.
Pantalé, Olivier +2 more
core +1 more source
Review of calibration strategies for discrete element model in quasi-static elastic deformation
Scientific Reports, 2023 This study first reviewed theories of the mechanical response of structures under loading, and the discrete element method provides a route for studying mechanical response including elastic deformation and structure failure.
Xianyang Liu +3 more
doaj +1 more source