Results 51 to 60 of about 117,272 (312)

An Energy-Based Discrete Element Modeling Method Coupled with Time-Series Analysis for Investigating Deformations and Failures of Jointed Rock Slopes

Applied Sciences, 2021
The discrete element method (DEM) can be effectively used in investigations of the deformations and failures of jointed rock slopes. However, when to appropriately terminate the DEM iterative process is not clear.
Xiaona Zhang, Gang Mei, Ning Xi, Ziyang Liu, Ruoshen Lin   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Simulation of penetration problems in geomechanics [PDF]

, 2017
The simulation of penetration problems in geomaterials is a challenging problem as it involves large deformations and displacements as well as strong non-linearities affecting material behaviour, geometry and contact surfaces. The paper presents examples
Gens Solé, Antonio, Ciantia, Matteo Oryem, Monforte Vila, Lluís, Carbonell Puigbó, Josep Maria, Arroyo Álvarez de Toledo, Marcos   +4 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A review of computational approaches for simulating fracturing mechanisms in layered rock formations

International Journal of Coal Science & Technology
With the increasing availability and sophistication of computer hardware and software, computational modelling has become a cornerstone in the understanding of geomaterials mechanical behaviours over recent decades.
Hongtao Li, Jimeng Feng, Dong Su, Xiangsheng Chen, Xingsen Guo   +4 more
doaj   +1 more source

LOCALIZATION OF SOLUTION OF THE PROBLEM OF THREE-DIMENSIONAL THEORY OF ELASTICITY WITH THE USE OF B-SPLINE DISCRETE-CONTINUAL FINITE ELEMENT METHOD

International Journal for Computational Civil and Structural Engineering, 2023
Localization of solution of the problem of three-dimensional theory of elasticity with the use of B-spline discrete-continual finite element method (specific version of wavelet-based discrete-continual finite ele-ment method) is under consideration in ...
Marina Mozgaleva, Pavel Akimov
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Tensile response of the muscle-tendon complex using discrete element model [PDF]

, 2014
Tear of the muscle-tendon complex (MTC) is one of the main causes of sport injuries (De Labareyre et al. 2005). However, the mechanisms leading to such injury are still unclear (Uchiyama et al. 2011). Before modeling the tear
GRAS, L., LAPORTE, Sébastien, GRAS, Laure-Lise, LECOMPTE, Jennyfer, IORDANOFF, Ivan, LECOMPTE, J, ROUX, Anthony   +6 more
core   +1 more source

State-of-the-Art Review and Prospect of Modelling the Dynamic Fracture of Rocks Under Impact Loads and Application in Blasting

Geosciences
The dynamic fracture of rocks under impact loads has many engineering applications such as rock blasting. This study reviews the recent achievements of investigating rock dynamic fracturing and its application in rock blasting using computational ...
Muhammad Kamran, Hongyuan Liu, Daisuke Fukuda, Peng Jia, Gyeongjo Min, Andrew Chan   +5 more
doaj   +1 more source