Results 61 to 70 of about 954,008 (282)

Discrete Element Method in der Geotechnik [PDF]

PAMM, 2007
AbstractIn der Discrete Element Method (DEM) werden Böden als Granulat betrachtet, das aus einem System einzelner Partikel besteht, dieüber Kontaktkräfte miteinander in Wechselwirkung stehen und sich gegeneinander verschieben können. In dem hier verwendeten zweidimensionalen Modell werden die Partikel als konvexe unregelmäßige Polygone modelliert ...
E. Heesen, E. Kreuzer
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

State-of-the-Art Review and Prospect of Modelling the Dynamic Fracture of Rocks Under Impact Loads and Application in Blasting

Geosciences
The dynamic fracture of rocks under impact loads has many engineering applications such as rock blasting. This study reviews the recent achievements of investigating rock dynamic fracturing and its application in rock blasting using computational ...
Muhammad Kamran, Hongyuan Liu, Daisuke Fukuda, Peng Jia, Gyeongjo Min, Andrew Chan   +5 more
doaj   +1 more source

Manuscripts Using Numerical Discrete Element Methods [PDF]

Rock Mechanics and Rock Engineering, 2013
The creation of numerical discrete element methods was a breakthrough in modeling discontinuous media and thus in modeling of rock masses. Recent developments in this domain, as also shown in a Special Issue of our Journal (Volume 45, Issue 5, September 2012), make it possible to simulate rock on any scale from intact rock composed of several particles
Barla, Giovanni, Kovari, Kalman, Einstein, Herbert H   +2 more
openaire   +3 more sources

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Modeling of Asphalt Concrete While Using Discrete Element Method

Наука и техника, 2019
The paper considers a mathematical model which is used to study a composite material similar in structure to asphalt concrete and it takes into account presence of solid particles of different sizes and a soft and plastic binder.
V. V. Alekseenko, K. Yu. Vabishchevich, E. V. Verkhoturova   +2 more
doaj   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Improvement of spheropolyhedral-based discrete element method and its application in fracture process of rock mass

Yantu gongcheng xuebao
In order to accurately simulate the evolution process of fractures, a three-dimensional deformable spheropolyhedral-based discrete element method is proposed by combining the finite element method with the spheropolyhedral-based discrete element method ...
ZHANG Decang , MAO Jia , DAI Miaolin , SHAO Linyu , ZHAO Lanhao
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

ABOUT SOLUTION OF MULTIPOINT BOUNDARY PROBLEMS OF THREE-DIMENSIONAL STRUCTURAL ANALYSIS WITH THE USE OF COMBINED APPLICATION OF FINITE ELEMENT METHOD AND DISCRETE-CONTINUAL FINITE ELEMENT METHOD. PART 1: FORMULATION AND BASIC PRINCIPLES OF APPROXIMATION

International Journal for Computational Civil and Structural Engineering, 2018
The distinctive paper is devoted to formulation and basic principles of approximation of multipoint boundary problem of static analysis of three-dimensional structure with the use of combined application of finite element method and discrete-continual ...
Pavel A. Akimov, Oleg A. Negrozov
doaj   +1 more source