Results 31 to 40 of about 4,541 (265)
A coupled fluid FEM-DEM technique for predicting blasting operations in tunnels
Underground Space, 2018 We present recent developments in the coupling of the finite element method (FEM) and the discrete element method (DEM) for the analysis of rock blasting operations in tunnels.
Francisco Zárate +4 more
doaj +1 more source
Pharmaceutics, 2021 The purpose of this work is to simulate the powder compaction of pharmaceutical materials at the microscopic scale in order to better understand the interplay of mechanical forces between particles, and to predict their compression profiles by ...
Kostas Giannis +3 more
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Advances in Materials Science and Engineering, 2021 This paper presents a coupled discrete-finite element method for the investigation of shear strength of geogrid-reinforced ballast by direct shear tests and pull-out tests. The discrete element method (DEM) and finite element method (FEM) are employed to
Danyang Ji +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Performance based simulation of pervious concrete using discrete element method
Građevinar, 2020 Pervious concrete is a special type of concrete that differs from ordinary concrete by its highly porous nature, which is why this type of discrete material can not be modelled using the Finite Element Method (FEM). Behaviour of pervious concrete samples
Ashfaque Ansari, Mukund M. Mahajan
doaj +1 more source
Calibration of soil compaction behavior using Discrete Element Method (DEM)
2017 Spokane, Washington July 16 - July 19, 2017, 2017 Abstract. Soil compaction has potential to reduce crop yield by resisting seed germination and root growth. Modern agricultural farm equipment is getting bigger in size and axle weight that could cause excessive soil compaction. Natures of soil compaction in agricultural fields are not predictable because of non-homogeneous soil condition, and ...
Sadek, Mohammad +2 more
openaire +3 more sources