Results 41 to 50 of about 4,813 (265)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Slope Failure of Noncohesive Media Modelled with the Combined Finite–Discrete Element Method
Applied Sciences, 2019 Slope failure behaviour of noncohesive media with the consideration of gravity and ground excitations is examined using the two-dimensional combined finite⁻discrete element method (FDEM).
Xudong Chen, Hongfan Wang
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Macro-Micro Study on Mechanical Properties of Frozen Fine Sandstone Based on DEM Mathematical Model
Journal of Function Spaces, 2022 The study of freezing rock mechanical properties is getting more and more urgent because of coal mine construction in western China. Particle discrete element method (DEM) can describe discontinuous medium problem mathematically.
Maoyan Ma +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Certain Discrete Element Methods in Problems of Fracture Mechanics
Acta Polytechnica, 2002 In this paper two discrete element methods (DEM) are discussed. The free hexagon element method is considered a powerful discrete element method, which is broadly used in mechanics of granular media.
P. P. Procházka, M. G. Kugblenu
doaj
HYBRID FINITE-DISCRETE ELEMENT MODELLING OF BLAST-INDUCED EXCAVATION DAMAGED ZONE IN THE TOP-HEADING OF DEEP TUNNELS [PDF]
Civil Engineering Journal, 2017 A hybrid finite-discrete element method (FEM/DEM) is introduced to model the excavation damage zone induced by blast in a deep tunnel. The key components of the hybrid finite-discrete element method, i.e. transition from continuum to discontinuum through
Huaming An +4 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source