Results 61 to 70 of about 87,723 (296)

Analysis and optimization of material flow inside the system of rotary coolers and intake pipeline via discrete element method modelling [PDF]

, 2018
There is hardly any industry that does not use transport, storage, and processing of particulate solids in its production process. In the past, all device designs were based on empirical relationships or the designer's experience.
Hlosta, Jakub, Nečas, Jan, Ramirez-Gomez, Alvaro, Rozbroj, Jiří, Zegzulka, Jiří, Žurovec, David   +5 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Macro-Micro Study on Mechanical Properties of Frozen Fine Sandstone Based on DEM Mathematical Model

Journal of Function Spaces, 2022
The study of freezing rock mechanical properties is getting more and more urgent because of coal mine construction in western China. Particle discrete element method (DEM) can describe discontinuous medium problem mathematically.
Maoyan Ma, Min You, Shuguang Peng, Biao Zhang, Yuan Lin   +4 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

HYBRID FINITE-DISCRETE ELEMENT MODELLING OF BLAST-INDUCED EXCAVATION DAMAGED ZONE IN THE TOP-HEADING OF DEEP TUNNELS [PDF]

Civil Engineering Journal, 2017
A hybrid finite-discrete element method (FEM/DEM) is introduced to model the excavation damage zone induced by blast in a deep tunnel. The key components of the hybrid finite-discrete element method, i.e. transition from continuum to discontinuum through
Huaming An, Hongyuan Liu, Xuguang Wang, Jianjun Shi, Haoyu Han   +4 more
doaj   +1 more source

GPU Accelerated Discrete Element Method (DEM) Molecular Dynamics for Conservative, Faceted Particle Simulations

, 2016
Faceted shapes, such as polyhedra, are commonly found in systems of nanoscale, colloidal, and granular particles. Many interesting physical phenomena, like crystal nucleation and growth, vacancy motion, and glassy dynamics are challenging to model in ...
Anderson, Joshua A., Glotzer, Sharon C., Marson, Ryan L., Spellings, Matthew   +3 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Certain Discrete Element Methods in Problems of Fracture Mechanics

Acta Polytechnica, 2002
In this paper two discrete element methods (DEM) are discussed. The free hexagon element method is considered a powerful discrete element method, which is broadly used in mechanics of granular media.
P. P. Procházka, M. G. Kugblenu
doaj  

On the Importance of Displacement History in Soft-Body Contact Models [PDF]

, 2016
Two approaches are commonly used for handling frictional contact within the framework of the discrete element method (DEM). One relies on the complementarity method (CM) to enforce a nonpenetration condition and the Coulomb dry-friction model at the ...
Fleischmann, Jonathan A., Jayakumar, Paramsothy, Negrut, Dan, Serban, Radu   +3 more
core   +1 more source