Results 51 to 60 of about 87,723 (296)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Pore-scale modeling of fluid-particles interaction and emerging poromechanical effects
, 2013 A micro-hydromechanical model for granular materials is presented. It combines the discrete element method (DEM) for the modeling of the solid phase and a pore-scale finite volume (PFV) formulation for the flow of an incompressible pore fluid.
Barthélémy, Eric +2 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Tensile response of the muscle-tendon complex using discrete element model [PDF]
, 2014 Tear of the muscle-tendon complex (MTC) is one of the main causes of sport injuries (De Labareyre et al. 2005). However, the mechanisms leading to such injury are still unclear (Uchiyama et al. 2011). Before modeling the tear
GRAS, Laure-Lise +4 more
core +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Advances in Materials Science and Engineering, 2021 This paper presents a coupled discrete-finite element method for the investigation of shear strength of geogrid-reinforced ballast by direct shear tests and pull-out tests. The discrete element method (DEM) and finite element method (FEM) are employed to
Danyang Ji +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Performance based simulation of pervious concrete using discrete element method
Građevinar, 2020 Pervious concrete is a special type of concrete that differs from ordinary concrete by its highly porous nature, which is why this type of discrete material can not be modelled using the Finite Element Method (FEM). Behaviour of pervious concrete samples
Ashfaque Ansari, Mukund M. Mahajan
doaj +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Slope Failure of Noncohesive Media Modelled with the Combined Finite–Discrete Element Method
Applied Sciences, 2019 Slope failure behaviour of noncohesive media with the consideration of gravity and ground excitations is examined using the two-dimensional combined finite⁻discrete element method (FDEM).
Xudong Chen, Hongfan Wang
doaj +1 more source