Results 31 to 40 of about 114,207 (267)

Fault Diagnosis in Fuzzy Discrete Event System: Incomplete Models and Learning

International Journal of Prognostics and Health Management, 2015
Nowadays, determining faults in non-stationary environment and that can deal with the problems of fuzziness impreciseness and subjectivity is a challenging task in complex systems such as nuclear center, or wind turbines, etc. Our objective in this paper
M. Traore, Eric Châtelet, Eddie Soulier, Hossam A. Gabbar   +3 more
doaj   +1 more source

Optimization of Overcast Stripping Technology Parameters Based on Discrete Event System Simulation

Advances in Civil Engineering, 2022
In the process of open-pit mining, the system parameters determine the economic benefit and production efficiency of the mine. Conventional optimization involves building a system model for the process parameters.
Zhang Zhao, Ruixin Zhang, Jiandong Sun, Shuaikang Lv   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Event-Triggered Continuous-Discrete Kalman Filter With Controllable Estimation Error

IEEE Access, 2018
In this paper, we first study the event-triggered continuous-discrete Kalman filtering problem to control the MSE under a given triggering threshold, where if the mean squared error (MSE) is smaller than this threshold, then an event is triggered to let ...
Yifeng Niu, Yirui Cong, Lizhen Wu
doaj   +1 more source

Reformulation for the Diagnosis of Discrete-Event Systems

Annual Conference of the PHM Society, 2010
Diagnosis is traditionally defined on a space of hypotheses (typically, all the combinations of zero or more possible faults).In the present paper, we argue that a suitable reformulation of this hypothesis space can lead to more efficient diagnostic algorithms and more compact diagnoses, most notably by exploiting opportunities for various forms ...
Grastien A., Torta G.
openaire   +3 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A discrete event model for real time system simulation

Journal of Computer Science and Technology, 2012
In this work we present a discrete event model to design and implement a real time system simulator. This kind of software is useful to verify and evaluate algorithms and models, and to compute performance metrics. The discrete event model fits perfectly
Francisco E. Páez, José M. Urriza, Carlos Buckle, Lucas Schorb, Javier D. Orozco   +4 more
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