Results 41 to 50 of about 815,297 (348)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Synthesis of Covert Actuator Attackers for Free

open access: yes, 2020
In this paper, we shall formulate and address a problem of covert actuator attacker synthesis for cyber-physical systems that are modelled by discrete-event systems.
Lin, Liyong, Su, Rong, Zhu, Yuting
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Distributed voltage control in electrical power systems [PDF]

open access: yes, 2009
Voltage instability stems from the attempt of load dynamics to restore power consumption beyond the capability of the combined transmission and generation system.
Boel, René, Moradzadeh, Mohammad
core   +1 more source

State-Based Control of Fuzzy Discrete Event Systems

open access: yes, 2005
To effectively represent possibility arising from states and dynamics of a system, fuzzy discrete event systems as a generalization of conventional discrete event systems have been introduced recently.
Cao, Yongzhi   +2 more
core   +3 more sources

Enhancing simulation education with intelligent tutoring systems [PDF]

open access: yes, 1996
The demand for education in the area of simulation is in the increase. This paper describes how education in the field of simulation can take advantage of the virtues of intelligent tutoring with respect to enhancing the educational process.
Siemer, J, Taylor, SJE
core   +1 more source

Fault Diagnosis in Fuzzy Discrete Event System: Incomplete Models and Learning

open access: yesInternational Journal of Prognostics and Health Management, 2015
Nowadays, determining faults in non-stationary environment and that can deal with the problems of fuzziness impreciseness and subjectivity is a challenging task in complex systems such as nuclear center, or wind turbines, etc. Our objective in this paper
M. Traore   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Verification of the observer property in discrete event systems [PDF]

open access: yes, 2014
The observer property is an important condition to be satisfied by abstractions of Discrete Event System (DES) models. This technical note presents a new algorithm that tests if an abstraction of a DES obtained through natural projection has the observer
Bravo, H. J.   +5 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

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