Results 41 to 50 of about 335,481 (263)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Digital Twin-Driven Multi-Factor Production Capacity Prediction for Discrete Manufacturing Workshop
Applied SciencesTraditional capacity forecasting algorithms lack effective data interaction, leading to a disconnection between the actual plan and production. This paper discusses the multi-factor model based on a discrete manufacturing workshop and proposes a digital ...
Hu Cai, Jiafu Wan, Baotong Chen
doaj +1 more source
Results in Physics, 2021 The main idea of this paper is to search for all traveling wave solutions to an intrinsic fractional discrete nonlinear electrical transmission line, which plays a essential role in obtaining the new insights in nonlinear voltage dynamics.
Shuangqing Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
A Discrete-Time FOLQR Framework for Centralized AGC in Multi-Area Interconnected Power Grids
Applied SciencesThis paper presents a discrete-time, centralized fractional-order linear quadratic regulator FOLQR for automatic generation control (AGC) of three-area interconnected nonreheat thermal systems.
Khidir AK Mohamed +2 more
doaj +1 more source
Commissioning of a production line in the discrete event simulation software Ururau
GEPROS: Gestão da Produção, Operações e Sistemas, 2017 The aim of this work was to demonstrate the utilization of a discrete event simulation model built with the Ururau software integrated to a programmable logic controller to be applied in commissioning of control systems.
Quézia Manuela Gonçalves Laurindo +5 more
doaj +1 more source
The Discrete and Continuum Broken Line Process
, 2009 In this work we introduce the discrete-space broken line process (with discrete and continues parameter values) and derive some of its properties. We explore polygonal Markov fields techniques developed by Arak-Surgailis. The discrete version is presented first and a natural continuum generalization to a continuous object living on the discrete lattice
L. Rolla +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source