Results 51 to 60 of about 335,481 (263)

Collaborative Training of Gans in Continuous and Discrete Spaces for Text Generation

IEEE Access, 2020
Applying generative adversarial networks (GANs) to text-related tasks is challenging due to the discrete nature of language. One line of research resolves this issue by employing reinforcement learning (RL) and optimizing the next-word sampling policy ...
Yanghoon Kim, Seungpil Won, Seunghyun Yoon, Kyomin Jung   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Generalized Voronoi Diagram-Based Segment-Point Cyclic Line Segment Matching Method for Stereo Satellite Images

Remote Sensing
Matched line segments are crucial geometric elements for reconstructing the desired 3D structure in stereo satellite imagery, owing to their advantages in spatial representation, complex shape description, and geometric computation.
Li Zhao, Fengcheng Guo, Yi Zhu, Haiyan Wang, Bingqian Zhou   +4 more
doaj   +1 more source

Design and Implementation of Discrete Multitone Modulator for Digital Subscriber Line Using FPGA [PDF]

Engineering and Technology Journal, 2014
This paper presents a design, simulation and implementation of the Discrete Multitone (DMT) modulator for digital subscriber line (DSL) for both complex and real transmission based on Software Defined Radio (SDR) using FPGA.
Hadi T. Ziboon, Ikhlas M. Farhan
doaj   +1 more source

The Discrete Resource Allocation Problem in Flow Lines [PDF]

Management Science, 1995
In this paper we address the discrete resource allocation problem in a deterministic flow line. We assume that the processing times are convex and nonincreasing in the amount of resources allocated to the machines. We consider the resource allocation problem for a fixed sequence of jobs for various performance criteria (makespan, weighted sum of ...
Selcuk Karabati, Panagiotis Kouvelis, Gang Yu   +2 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Discrete Wavelet Multi-Tone Transmission for Digital Subscriber Line

Journal of Engineering and Sustainable Development, 2005
Multi-Carrier Modulation (MCM) is an attractive technique for copper wire access technology in high-performance communication networks (e.g. Asymmetric and Very-high-rate Digital Subscriber Line). In digital implementations of MCM, subcarrier generation
Abdul-Karim Abdul-Rahman Kadhim
doaj  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source