Results 51 to 60 of about 37,742 (304)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Research on a Real-Time Control System for Discrete Factories Based on Digital Twin Technology
Applied SciencesGear factories are most typical discrete manufacturing factories. Many gear factories are striving to explore how to achieve intelligent manufacturing in order to improve efficiency and reduce costs.
Shousong Jin +4 more
doaj +1 more source
Development of frameworks for steel manufacturing planning capability improvement using discrete event simulation [PDF]
, 2013 Customers of a steel manufacturing company now order a large number of low volume orders instead of a small number of high volume orders as they would have done just a few decades ago.
Borisoglebsky, Dmitry
core
Temporal analysis of event-discrete alarm data for improved manufacturing
, 2022 S.742-746Efficient response to machine failures is crucial for improving machine availability. In practice, the number of alarms occurring during the operation of manufacturing systems could overwhelm even experienced machine operators.
Putz, Matthias +3 more
core +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
The development of discrete-address manufacturing planning method
MATEC Web of Conferences, 2017 The article describes the main stages of building the discrete-address manufacturing planning method. The developed discrete-address method ensures manufacturing of part sets “Just-in-Time” for high-variety manufacturing, using the vector planning in the
Polyanskov Yuri +2 more
doaj +1 more source
Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang +21 more
wiley +1 more source
MathematicsDiscrete manufacturing environments face increasing challenges in managing work-in-process (WIP) inventory due to growing product customization and demand volatility.
Ben Liu, Yan Li, Feng Gao
doaj +1 more source
Finding Clusters in Petri Nets. An approach based on GPenSIM [PDF]
Modeling, Identification and Control, 2019 Graph theory provides some methods for finding clusters in networks. Clusters reflect the invisible grouping of the elements in a network. This paper presents a new method for finding clusters in networks.
Reggie Davidrajuh +2 more
doaj +1 more source