Results 31 to 40 of about 162,308 (216)
Approximate Nonlinear Discrete-Time Models Based on B-Spline Functions
IEEE Access, 2020 We consider the discretization of continuous-time nonlinear systems described by normal forms. In particular, we consider the case when the input to the system is generated by a B-spline hold device to obtain an approximate discrete-time model.
Claudia Sanchez, Juan I. Yuz
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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On the analytic form of the discrete Kramer sampling theorem
International Journal of Mathematics and Mathematical Sciences, 2001 The classical Kramer sampling theorem is, in the subject of self-adjoint boundary value problems, one of the richest sources to obtain sampling expansions. It has become very fruitful in connection with discrete Sturm-Liouville problems.
Antonio G. García +2 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Discrete Wavelet Transform Sampling for Image Super Resolution
Applied Artificial IntelligenceIn battlefield environments, drones depend on high-resolution imagery for critical tasks such as target identification and situational awareness. However, acquiring clear images of distant targets presents a significant challenge.
Chieh-Li Chen, Heng-Lin Yao, Bo-Lin Jian
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Implementing Discrete Model of Photovoltaic System on the Embedded Platform for Real-Time Simulation
Energies, 2020 This paper presents the development of a discrete model of a photovoltaic (PV) system consisting of a PV panel, Maximum Power Point Tracking (MPPT), a dual-axis solar tracker, and a buck converter.
Aryuanto Soetedjo +1 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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