Results 51 to 60 of about 22,371,115 (244)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Supremica – An integrated environment for verification, synthesis and simulation of discrete event systems [PDF]

, 2006
An integrated environment, Supremica, for verification, synthesis and simulation of discrete event systems is presented. The basic model in Supremica is finite automata where the transitions have an associated event together with a guard condition and an
\uc5kesson, Knut, Hugo Flordal, Flordal, Hugo, Malik, Robi, Knut Akesson, Akesson, Knut, Robi Malik, Martin Fabian, Fabian, Martin   +8 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A note on control of a class of discrete-time stochastic systems with distributed delays and nonlinear disturbances [PDF]

, 2010
The official published version of this article can be found at the link below.This paper is concerned with the state feedback control problem for a class of discrete-time stochastic systems involving sector nonlinearities and mixed time-delays. The mixed
Liu, Y, Wei, Guoliang., Liu, X, Wang, Z, Liu, Xiaohui., Wang, Zidong., Yurong Liu (9814022), Z Wang (81545), G Wei (7777079), X Liu (7756691), Wei, G, Liu, Yurong.   +11 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

On periodic orbits in discrete-time cascade systems

Discrete Dynamics in Nature and Society, 2006
We present some results on existence, minimum period, number of periodic orbits, and stability of periodic orbits in discrete-time cascade systems. Some examples are presented to illustrate these results.
Huimin Li, Xiao-Song Yang
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Generalized observer forms for discrete-time nonlinear systems [PDF]

Proceedings of the Estonian Academy of Sciences
The paper addresses the problem of transforming single-output discrete-time state equations into the generalized observer form, which comprises a linear observable component and a nonlinear injection term, depending on the inputs, output, and a finite ...
Arvo Kaldmäe, Ülle Kotta, Vadim Kaparin, Tanel Mullari, Maris Tõnso, Ewa Pawłuszewicz   +5 more
doaj   +1 more source

H ∞  sliding mode observer design for a class of nonlinear discrete time-delay systems: A delay-fractioning approach [PDF]

, 2011
Copyright @ 2012 John Wiley & SonsIn this paper, the H ∞  sliding mode observer (SMO) design problem is investigated for a class of nonlinear discrete time-delay systems.
Zidong Wang, Wang, Z, Stergioulas, LK, Jun Hu, Hu, J, Lampros K. Stergioulas, Niu, Y, Yugang Niu   +7 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source