Results 71 to 80 of about 971,440 (314)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Optimal Discretion [PDF]

Finance and Economics Discussion Series, 1999
This paper investigates the desirability of adopting a rule in favor of discretionary monetary policy in a model exhibiting Kydland and Prescott's dynamic inconsistency problem. We deviate from earlier work by adopting assumptions regarding policymaker preferences and inflation dynamics that are compatible with empirically motivated models used for ...
Lengwiler, Yvan, Orphanides, Athanasios
openaire   +2 more sources

Surface Fermi Level Modulation of Photoanode by Optimized Conducting Nanoparticle Heterointerfaces for Enhanced Photoelectrochemical Water Splitting

Advanced Science, EarlyView.
Optimizing the heterointerface coverage of the conducting Ni2P nanoparticles on the surface of BVO photoanode manipulates the surface Fermi‐level modulation, which significantly enhances photoelectrochemical oxygen evolution reaction. Our multiscale simulations and experimental results reveal that an optimal Ni2P coverage of 9.4% pins the surface Fermi
Phuong Thi Pham, Seulgi Ji, Unbeom Baeck, Yuankai Li, Duong Nguyen Nguyen, Won Tae Hong, Yang You, John Moraros, Kyoungsuk Jin, Jun Young Lee, Chan‐Hwa Chung, Tae‐Hoon Kim, Jongwook Park, Heechae Choi, Jung Kyu Kim   +14 more
wiley   +1 more source

Competition Policy and Agribusiness in the Biden Administration

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The Biden Administration pursued a set of ambitious competition policy initiatives in agriculture and agribusiness, primarily aimed at livestock and poultry supply chains, farm inputs, and food retailing. The initiatives included expanded antitrust enforcement; new US Department of Agriculture (USDA) contract regulations requiring poultry ...
James M. MacDonald
wiley   +1 more source

The Role of Discretion in Professional Practice

Annales Etyka w Życiu Gospodarczym, 2016
Various scholars of ethics and economics conduct research on the best modes of decision making which guarantee good outcome and moral behaviour of the individuals involved. Either of the modes considered, rules with regulations or discretion and judgment,
Piotr Wajszczyk
doaj   +1 more source

Discrete gap probabilities and discrete Painlevé equations

Duke Mathematical Journal, 2003
We prove that Fredholm determinants of the form det(1-K_s), where K_s is the restriction of either the discrete Bessel kernel or the discrete {}_2F_1 kernel to {s,s+1,...}, can be expressed through solutions of discrete Painleve II and V equations, respectively.
openaire   +3 more sources

Law and Nonlegal Norms in Government Lawyers\u27 Ethics: Discretion Meets Legitimacy [PDF]

, 2019
This Essay is about the role of unwritten norms in the ethical decisionmaking of government lawyers. Because the ethical obligations of lawyers, including government lawyers, are closely tied to the legal rights and obligations of clients, this analysis ...
BÜYÜKKILIÇ BEYZİ, SELMA, KALİBER, MAHMUT, KONCA, YUSUF, YALÇIN, HASAN, YÜKSEL, TUBA   +4 more
core   +2 more sources

The Biofuels Blueprint: Understanding the U.S. Renewable Fuel Standard

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We provide a comprehensive review of the U.S. Renewable Fuel Standard (RFS), synthesizing nearly two decades of program evolution, market outcomes, and economic analysis. The RFS mandates minimum volumes of renewable fuel blending through a nested structure based on life‐cycle greenhouse gas reductions, enforced via tradeable Renewable ...
Maria Gerveni, Todd Hubbs, Scott H. Irwin, James H. Stock   +3 more
wiley   +1 more source

Neo-constitutional theory of administrative discretion

Revista Eurolatinoamericana de Derecho Administrativo
This study has as its object the administrative discretion in the light of the premises of neo-constitutionalism. It distinguishes the legalist theory, in which the source of discretion is the legislation, from the neo-constitutionalist theory, in which ...
Ricardo Marcondes Martins
doaj   +1 more source

Discrete Spacings

Statistica Neerlandica, 2003
Consider a string of n positions, i.e. a discrete string of length n. Units of length k are placed at random on this string in such a way that they do not overlap, and as often as possible, i.e. until all spacings between neighboring units have length less than k. When centered and scaled by n−1/2 the resulting numbers of spacings of length 1, 2,…, k−1
Klaassen, C.A.J., Runnenburg, J.T.
openaire   +6 more sources